354 proteins with sex-biased expression identified in the current work (Supplementary Table16). Moreover, we found that 25% of the causal genes in brain traits, on average, had sex-biased protein expression (range 5–50%; Fig.3a). Further...
Lean Body Mass There was no significant effect of protein level on LBM over 6 months. The changes in LBM did not differ among men assigned to 0.8 vs 1.3 g/kg/d of protein (effect size, 0.31 kg; 95% CI, −0.46 to 1.08 kg; P = .43) regardless of whether they received testo...
Glycation is a posttranslational modification formed by the nonenzymatic binding of various sugars to globin chain amino groups over the life span of the RBC. The most characterized of the glycated hemoglobins is Hb A1c, in which glucose attaches to the N-terminal valine of the β chain.1 Nor...
The in vivo protein corona is analysed over time to understand mechanisms that increase the blood residency time of NPs. This study confirmes that the evolution of the in vivo protein corona is highly dynamic and the corona, composed of several opsonins, fluctuates as NPs circulate in the ...
The forces are effective over approximately twice the double layer thickness. See DLVO theory. electrotonus The state of a nerve during the brief period that an electrical current is passing. elegantin See disintegrin. eleidin Clear substance found in stratum lucidum of skin, derived from kerato...
Moreover, 1-SD increment of ABSI and logarithm CRP were 1.18 (0.94-1.47) and 1.18 (0.90-1.55), respectively. Table 2. Hazard Ratios and 95% Confidence Intervals of Ischemic Stroke with ABSI and CRP Items Unadjusted Age and Gender Adjusted Multivariable Adjusted* HR 95% CI HR 95% CI HR...
With 1.7% MAF, it is over 4-fold enriched in the Finnish population. Previously, p.Thr405Met has been identified to cause hepatic lipase deficiency in a compound heterozygous state with another rare p.Ser301Phe mutation in LIPC, causing elevated total cholesterol, triglyceride, and triglyceride...
Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attentio
After one wash with high‐salt buffer and two washes with PNK buffer (50 mM Tris–HCl pH 7.4, 10 mM MgCl2, 0.1 mM spermidine), the beads were resuspended in 1 ml NP-T buffer and stored at 4 °C overnight. After washing the beads with 1 ml PNK buffer, the ...
1 A–H illustrates Bland–Altman plots of mean differences and limits of agreement between actual or corrected bodyweight and FFM, stratified for BMI categories for men and female separately. Clinically relevant differences were found in protein requirement between actual bodyweight and FFM in most ...