36,40,41,42,43, including the loss of cell surface proteoglycans35,36,40,41,42,43and expression of angiogenesis inhibiting growth factors44. Diabetic patients in particular have reduced recruitment of stem cells to ischemic regions, circulating EPCs, and endothelial cell function45,46. We ...
G protein-coupled receptors (GPCRs) can affect insulin action, insulin secretion and β-cell expansion, and certain GPCRs have emerged as potential drug targets for the development of anti-diabetic therapeutics. Decreased insulin sensitivity is a major metabolic defect in the great majority of indiv...
Clinical Application of the Nonenzymatic Glycation of Hair Protein in Diabetic Patients The assay of furosine, an acid-hydrolysis product derived from fructose-lysine in glycated protein, was used as a specific method for determining Amadori c......
Sari M, Kilic H, Karakurt Ariturk O, Yazihan N, Ak- demir R. Diabetic patients have increased perioper- ative cardiac risk in heart-type fatty acid-binding protein-based assessment. Med Princ Pract 2015; 24:53-7. [CrossRef]Munevver, Sari,Harun,etc.Diabetic patients have increased ...
An ATF6-dependent maladaptive ER response induced by impaired XBP1s nuclear translocation was observed in diabetic nephropathy [42]. In comparison with the control group, nuclear expressions of XBP1s are lower in both murine models of diabetic nephropathy and diabetic patients. Furthermore, the IRE...
Objective To explore the effects of ginkgo biloba extract and dipyridamole injection and irbesartan on urine protein in patients with diabetic nephropathy.Methods Sixty-eight patients in stage Ⅲ were divided into two groups:treatment group and control group(34 patients each).The treatment group was ...
the crystal structure of NEDD8 was resolved with 3D structure similar to ubiquitin.4Also in 1998, a new NEDD8-ligating system was established for cullin-4A, involving NEDD8 activation by NAE E1 and conjugation by UBC12 E2, eventually the attachment of NEDD8 to cullin-4A.27And also RUB1,...
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Conversely, diabetic patients display obvious abnormalities in protein glycosylation, including chitosidase (chit1)13 and immunoglobulin G (IgG)14. N-glycosylation map has been used as a biomarker to monitor the progression of early T2DM15. Therefore, we speculate that T2DM contributes to the ...
The diabetes drug metformin prevents this cooperation; in epidemiological studies it reduced the risk of tumours in diabetic patients. G protein-coupled receptor 30 (also known as G protein-coupled oestrogen receptor) mediates rapid effects induced by oestrogens and anti-oestrogens in boths normal ...