Rats made diabetic by injection of streptozotocin, either after adaptation to a cafeteria or some weeks beforehand, increased their intake of protein relative to that of other macronutrients. Preference for an arbitrary odor added to the protein was increased. Normal rats were repeatedly given brief ...
Targeting G protein-coupled receptors (GPCRs) in metabolic tissues — such as adipose tissue, liver, muscle, pancreatic islets, immune cells and the central nervous system — has emerged as a key target for current and future anti-diabetic compounds. This Opinion focuses on the potential of ...
Smith, U. Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance – is insulin resistance initiated in the adipose tissue? Int. J. Obes. Relat. Metab. Disord. 26, 897–904 (2002). CAS PubMed Google Scholar Ostman, A. & Bohmer, F. D. ...
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The BB Wistar rats, already diabetic for 5 weeks before being transferred to the HP or control diet, were treated with daily injections of insulin. After 31 days on the HP diet, the BB rats showed reduced insulin requirement, reduced blood and urinary glucose levels, but no difference in ...
For example, the emulsifying activity of surfactin produced by B. subtilis can change based on pH. With a pH above 7, it forms a stable emulsion with kerosene, but when the pH drops to 3 the emulsion does not form [66]. Figure 1. (A) NRPS modules of surfactin, iturin, and fengycin...
It mediates the effects of several important adipokines such as leptin and adiponectin and is thought to be responsible for the antidiabetic effects of metformin and thiazolidinediones. A diverse number of GPCRs (including adrenoceptors, cannabinoid receptors, ghrelin receptors, melanocortin ...
In particular, individuals with type 1 diabetes develop CVD early and carry a considerable CVD risk burden, with a 7.5-fold incidence ratio for coronary artery disease (CAD) vs. the general population; in the presence of other comorbidities such as diabetic kidney disease (DKD), this ratio is...
Therefore, gain or loss of nitrogen from the body represents gain or loss of protein; the amount of protein required to maintain nitrogen balance reflects the amount of protein required for optimal health.1 A nitrogen-balance study uses careful documentation of nitrogen intake, a diet adjustment ...
Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer. Clin. Cancer Res. 16, 2505–2511 (2010). Shows that metformin disrupts crosstalk between insulin/IGF I receptor...