Smith, U. Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance – is insulin resistance initiated in the adipose tissue? Int. J. Obes. Relat. Metab. Disord. 26, 897–904 (2002). CAS PubMed Google Scholar Ostman, A. & Bohmer, F. D. ...
Targeting G protein-coupled receptors (GPCRs) in metabolic tissues — such as adipose tissue, liver, muscle, pancreatic islets, immune cells and the central nervous system — has emerged as a key target for current and future anti-diabetic compounds. This Opinion focuses on the potential of ...
The chemical “toxoiding” procedure has the disadvantages of potential alteration of protective epitopes (with ensuing reduced immunogenicity) and the potential for reversion to a biologically active toxin. However,rDNAtechnology can be used to produce a stable toxoid. For example,pertussis toxinwas ...
Protein homeostasis, or proteostasis, is essential for cell function and viability. Unwanted, damaged, misfolded and aggregated proteins are degraded by th
"[It] has been a literal life saver for me. I have lost weight, no longer have fatty liver, and I am no longer pre-diabetic all from the weight loss." "Great taste and quality! We are using this protein as a team after lifting. Exactly what you need for recovery + taste like a...
A TG-to-HDL-C ratio ≥3.0 is suggestive of IR [14]. Finally, there are individuals who are classified as being prediabetic based on a fasting blood glucose level higher than the normal range, but not high enough to fit the diabetes criteria (i.e., a level between 100 and 125 mg/...
Milk proteins and milk protein-derived peptides have been widely studied for their health enhancing properties. This chapter presents the updated scientific knowledge on the bioactive properties of milk protein-derived peptides. The different bioactive p
High-resolution structures of cytoplasmic domains of GIRK channels provide a new 'toolbox' for investigating the molecular mechanisms underlying the gating and function of GIRK channels. Brain slice electrophysiology provides several examples of plasticity in the slow IPSCs mediated by GIRK channels that...
Mycoproteinis the ingredient name for a food-grade protein source that has been available for food use only since 1985. As the name suggests, this protein is made from a type of fungus,Fusarium venenatum(PTA 2684), that was found in the wild and developed specifically for the production of...
The present invention relates to the field of biopharmaceuticals, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use for treating diabetes. The fusion protein of the present invention is obtained by linking two polypeptides, wherein one polypeptide is an ...