6b). Here we find that distinct domains are often shared across protein clusters in context with various combinations of other domains, which can be seen with domains involved in interaction with the cytoskeleton (Extended Data Fig. 6c) and in metabolism (Extended Data Fig. 6d,e) in ...
. Our analysis result (Supplementary Fig.1) indicated that the relatively large prediction errors under two clustering settings may result from certain protein families, domains, and organisms (e.g., histone and GPCR for the protein families, trypsin and kringle for the domains, and bovine for ...
Tools and resources for identifying protein families, domains and motifs. Genome Biol. 2002;3(1):reviews2001.1-reviews2001.8. 10.1186.Mulder, N.J. and Apweiler, R. (2002) Tools and resources for identifying protein families, domains and motifs. Genome Biol 3(1), REVIEWS2001....
domains, motifs, or structures of candidate interacting protein pairs with those of known interacting protein pairs; while learning-based methods generate features from candidate and known interacting protein pairs for training a classifier or constructing rules for predictions. Illustration of these princip...
Use Standalone RPS-BLAST and rpsbproc(https://ftp.ncbi.nih.gov/pub/mmdb/cdd/rpsbproc/e) (这个网址好像失效了)to compute and retrieve(检索) domain annotation programmatically. Basic Protocol3demonstrates how to identify protein domains for a batch of protein queries of greater than 4000.演示了...
(ZmSUN3,ZmSUN4, andZmSUN5) encode slightly larger proteins with three transmembrane domains, a single SUN-domain that is not at the C-terminus but rather in the middle of the protein, and a highly-conserved domain of unknown function that we refer to as the PM3-associated domain (PAD)...
Protein phosphorylationhas become a central focus ofdrug discoveryas the result of the identification and validation of promising therapeutic targets such asprotein kinases, proteinphosphatases, andphosphoproteinbinding domains.1–24With respect to suchprotein phosphorylationtherapeutic targets, significant progres...
Other members of the PDI family differ substantially in terms of the a/b-domains configurations and other important motifs (Fig.1A). Phylogenetic analysis that is based on sequence similarities of PDI reveals the existence of multiple subfamilies, markedly the AGR (TXNDC12, AGR2, AGR3), TMX...
A biochemical basis for those relationships might be revealed by identifying which specific protein sequence domains and motifs are most responsible for the correlation of two traits. Therefore, a computational method to dissect and explain the origin of PPP's signal may provide a wealth of ...
domains) was identified to be the ortholog ofArabidopsisTTG1 in the mango genome database. In recent years, several WD40 proteins that are orthologs to theArabidopsisTTG1 gene have been identified in some plant species, such as cotton (Gossypium hirsutum),Prunus persica,Punica granatumand maize ...