Modulators of glucagon-like peptide 1 (GLP1) and the resulting G protein-coupled receptor (GPCR) signalling have recently come to the fore of the treatment of type 2 diabetes. In this Opinion article, Oh and Olefsky discuss the potential for intervention
Variation in the gene encoding dysbindin-1 (i.e., dystrobrevin-binding protein 1: DTNBP1) has frequently been associated with schizophrenia. Several studies have also found that dysbindin-1 gene and protein expression are altered in two affected brain ar
Interestingly, proteins related to ACBD8 exist in the more primitive reptilian groups of crocodiles and turtles, suggesting that this event occurred already at an earlier stage of amniotic evolution. Like in humans, predicted potential full-length ACBD8 protein sequences could not be retrieved from...
26 Besides, compared to traditional small molecule drugs (200–500 Da), drugs acting on PPIs have a higher molecular weight (>400 Da), which makes it challenging to meet the criteria like Lipinski’s “rule of 5”.23,27 Hot-spots Theoretically, the large binding interfaces are not ...
Milk proteins and milk protein-derived peptides have been widely studied for their health enhancing properties. This chapter presents the updated scientific knowledge on the bioactive properties of milk protein-derived peptides. The different bioactive p
MoleculeNet published a small molecule related benchmark four years ago. In terms of datasets and benchmarks, protein design is far less mature than drug discovery (paperwithcode drug discovery benchmarks). (Maybe should add the evaluation of protein design for deep learning method (especially ...
GJB1 Gap junction beta-1 protein ACTR3 Actin-like protein 3 PRKACA cAMP-dependent protein kinase catalytic subunit alpha LRP2 Low-density lipoprotein receptor-related protein 2 precursor ARVCF Armadillo repeat protein deleted in velo-cardio-facial syndrome CSNK1A1 Casein kinase I isoform alpha GJA1...
Gibbs GM, Lo JCY, Nixon B, Jamsai D, O’Connor AE, Rijal S, Sanchez-Partida LG, Hearn MTW, Bianco DM, O’Bryan MK: Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte...
Serine/threonine-protein kinase SMG1 简称 SMG-1||hSMG-1 别名 ATX, KIAA0421, LIP, phosphatidylinositol 3-kinase-related kinase 其他名 61E3.4Lambda/iota protein kinase C-interacting protein From Uniport SMG1 基因家族蛋白 Armadillo-like helical domain containing ...
where each subgraph is a subset of the next one. They then define a permutation-invariant descriptor function for each subgraph that is related to curvature. This function is designed to be invariant to the order in which the nodes are arranged, so that it can be used to characterize the ...