precursor-like protein 1Amyloid precursor proteinPlaquesThe Alzheimer's disease (AD) beta-amyloid precursor protein (APP) and the amyloid precursor-like protein 1 (APLP1) and 2 (APLP2) are members of a super-family of proteins that appear functionally related. Although APLPs are highly ...
its physiologic roles are still poorly understood.1,2,3There are two major pathways of APP processing. In the amyloidogenic pathway, APP is cleaved byβ-secretase at the N-terminus of the amyloidβ(Aβ) domain liberating sAPPβand membrane-bound ...
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(d) In addition to APP, vertebrates also express to closely related orthologs: APP-Like Protein 1 & 2 (APLP1 and APLP2). Both family members contain extracellular and intracellular protein interaction domains that are closely similar to these domains in APP and have been shown to have ...
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Amyloid precursor protein (APP) is an evolutionarily conserved protein with two homologues in mammals: amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) [1, 2]. APLP1 was identified as the first homologue of APP [3, 4], and APLP2 (also known as YWK...
APP is a member of a family of conserved type I membrane proteins. The APP orthologs have been identified in, among others, C. elegans [1], Drosophila [2, 3], Zebrafish [4] and Xenopus Laevis [5, 6]. Three APP homologs, namely APP [7, 8], APP like protein 1 (APLP1) [9] an...
The amyloid precursor protein (APP) and the APP-like proteins 1 and 2 (APLP1 and APLP2) are a family of multidomain transmembrane proteins possessing homo- and heterotypic contact sites in their ectodomains. We previously reported that divalent metal ions dictate the conformation of the ...
accepted 21.7.14; Edited by G Schiavo Soluble and membranous APP cooperate to induce Akt N Milosch et al 2 (and the mammalian paralogs APP-like protein 1 and 2 (APLP1/APLP2)) are integral transmembrane proteins with proposed functions as membrane-bound signaling receptors and/or adhesion mole...
and hormonal regulation. Secreted APP (sAPP) may have neuroprotective effects against neurotoxic insult, oxidative stress, and excitotoxicity. APP belongs to a family that contains at least two homologs, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2). Similarities between APP...