Biophysical characterizations and a cell viability assay revealed distinct effects of Lys and aLac on IAPP amyloid aggregation, fibril remodelling and cytotoxicity, pointing to the role of protein "corona" in conferring the biological impact of amyloidogenic peptides. Systematic molecular dynamics ...
Control over the protein corona of nanomaterials allows them to function better. Here, by taking graphene/gold as examples, we comprehensively assessed the association of surface properties with the protein corona. As revealed by in vitro measurements and computations, the interaction between graphene/...
Different protein coronae affect RSV infectivity and moDC activation.a,bRSV virions produced under serum-free conditions were pre-coated with different coronae via pre-incubation with different biological fluids prior to addition to HEp-2 cells in serum-free medium (diluted 10×) at an MOI of ...
(Dutta et al., 2020) and it was also found to induce T-cell immune responses. EpiVacCorona vaccine comprises protein N, which was chosen to be utilized as a carrier for peptide antigens owing to its high level of conservation and immunogenicity, as a valuable source of CD4+T-cell ...
It is thus feasible that incorporation of the S protein into the coronaviral envelope is mediated by interactions between the amphipathic domains of the two proteins. Besides for S protein incorporation into the viral envelope the membrane-proximal region of the spike protein is also of critical ...
Huge interests have been drawn to 2D nanomaterials for biomedical applications; however, the 2D bio-nano interface is largely dependent on the biological environment. Hard protein corona (HC)-dependent bio-nano interactions are highly sensitive to material surface functional group changes. Alterations in...
COMPOSITIONS, METHODS AND SYSTEMS FOR PROTEIN CORONA ANALYSIS FROM BIOFLUIDS AND USES THEREOF This disclosure provides methods and compositions for biomolecule corona analysis of biofluids. A biofluid may be contacted with a nanoparticle to form a b... X Zhao,W Manning,J Blume,... 被引量: 0发...
Using this envelope assembly assay, we have studied the primary sequence requirements for particle formation of the mouse hepatitis virus (MHV) M protein, the major protein of the coronavirion membrane. Our results show that each of the different domains of the protein is important. Mutations (...
Effects of surface functional groups on the formation of nanoparticle-protein corona Herein, we examined the dependence of protein adsorption on the nanoparticle surface in the presence of functional groups. Our UV-visible spectrophotometry... R Podila,R Chen,PC Ke,... - 《Applied Physics Letters...
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