Different protein coronae affect RSV infectivity and moDC activation.a,bRSV virions produced under serum-free conditions were pre-coated with different coronae via pre-incubation with different biological fluids prior to addition to HEp-2 cells in serum-free medium (diluted 10×) at an MOI of ...
Revealing the binding structure of the protein corona on gold nanorods using synchrotron radiation-based techniques: understanding the reduced damage in cell membranes. J. Am. Chem. Soc. 135, 17359–17368 (2013). Article CAS PubMed Google Scholar Lai, Z. W., Yan, Y., Caruso, F. & ...
Numerous works are also focusing to develop protease inhibiting compounds of life threatening viruses, e.g., hepatitis C virus [73] and human corona virus, responsible for acute respiratory syndrome [74]. In this direction, development of HIV-1 protease inhibitors was a major breakthrough to ...
To conclude, when integrating our CRL4A ligase ensemble (five conformations: c1, c2, c4, c5, and c9) with three different reported ternary complex structures, at least one lysine residue on the target protein surface was observed in close proximity to the Ub (∼11–16 Å). These model...
amyloid coronae [56]. A central finding in that study is that not all protein bind directly to Aβ. This illustrate that the assembly is more complex than just sequestration of the proteins by the amyloid structure. Moreover, the recent study from Nandakumaret al.[53] shows that the prote...
(see model in Supplementary Fig. 5a). In this regard, homophilic interaction with GPI-anchored PrP on EVs, binding to other surface receptors or association with the EV membrane or corona components are conceivable. As mentioned earlier, assessment of sPrP with classical pan-PrP antibodies is ...
the overlap between the proteins on the three NPs was analyzed using a Venn diagram (Supplementary Fig.11band Supplementary Table3). At each stage, approximately half of the proteins adsorbed on the NPs were in the soft corona layer, where they were weakly adsorbed on the NP surface and dyna...
Robust characterization of the protein corona—the layer of proteins that spontaneously forms on the surface of nanoparticles immersed in biological fluids—is vital for prediction of the safety, biodistribution, and diagnostic/therapeutic efficacy of nanomedicines. Protein corona identity and abundance chara...
c Deuterium labeling in the livers of mice does not reveal a difference in the rate of palmitate synthesis during statin-treatment (p = 0.8, n = 4 biological replicates, ANOVA, boxplot as in b). d Proximity ligation assay was performed on HepG2 cells and sites of HMGCR-FAS ...
Viruses of the family Coronaviridae possess a single stranded, positive-sense RNA genome ranging from 26 to 32 kilobases in length. Coronaviruses have been identified in several avian hosts, as well as in various mammals, including camels, bats, masked palm civets, mice, dogs, and cats. Novel...