Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial when it concerns fat mass, but loss of fat free mass – esp
The calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor1 (GPCR) that has a central role in regulating systemic calcium homeostasis2,3. Here we use cryo-electron microscopy and functional assays to investigate the activation of human CaSR embedded in lipid nanodiscs and it...
As of August 2022, there were more than 350 million unique protein sequences in UniProt (that is, UniRef100 clusters11). We focus our analysis on these as they have a higher confidence than those deposited in metagenomics databases such as MGnify. These sequences correspond to roughly 50...
Through this double sensitivity, a link is formed between protein and calcium metabolism. According to these findings, AAs would activate the CaSRs, reducing parathormone (PTH) production and decreasing renal calcium reabsorption, leading eventually to an increased calcium excretion (Conigrave et al....
Alzheimer’s disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ) peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary tangles. Extensive research has focused on understanding the asse
Proteins unadjusted (A, B) and adjusted (C, D) for age and sex were included for comparison. Linear predictors were selected based on results of stepAIC models of adjusted data for EOAD (E) and LOAD (F), with the best model based on highest AICs relative to model complexity plotted ...
Aberrant protein aggregation is a hallmark of many age-related diseases, yet little is known about whether proteins aggregate with age in a non-disease setting. Using a systematic proteomics approach, we identified several hundred proteins that become mo
Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave. Morimoto RI, Cuervo AM: Protein homeostasis and aging: taking care of proteins from the cradle to the grave. J Gerontol A Biol Sci Med Sci 2009, 64... Morimot,I Richard,Cuervo,... - 《Journals of Ge...
showing that the binding probability of the local region is 0.948 in HepG2 cells and 0.002 in K562 cells, respectively, indicating the possible existence of diverse gene expression in the different cells. Then, as shown in Fig.7c, we used the HepG2 model to scan the K562 data, and we...
A new generation of SARS-CoV-2 vaccines targeting the Omicron variant are urgently needed. Here, we developed a subunit vaccine named RBD-HR/trimer by directly linking the sequence of RBD derived from the Delta variant (containing L452R and T478K) and HR1 and HR2 in SARS-CoV-2 S2 ...