The calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor1 (GPCR) that has a central role in regulating systemic calcium homeostasis2,3. Here we use cryo-electron microscopy and functional assays to investigate the activation of human CaSR embedded in lipid nanodiscs and it...
Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial when it concerns fat mass, but loss of fat free mass – esp
Żyliäska L, Kosk-Kosicka D: Protein kinase C catalyzed phosphorylation of plasma membrane Ca2+-ATPase from cerebellum and redcells. Biophys J 66: A119, 1994 Google Scholar Booth RFG, Clark JB: A rapid method for the preparation of relatively pure metabolically competent synaptosomes from ...
aCircos plot of the extracted binding motifs of all 172 RBP datasets. RBPs involved in the same RNA regulatory pathway are generally grouped together via hierarchical clustering.bLIN28B binding probabilities and saliency maps in HepG2 and K562 cells and the visualization of the RNA structure.cS...
Through this double sensitivity, a link is formed between protein and calcium metabolism. According to these findings, AAs would activate the CaSRs, reducing parathormone (PTH) production and decreasing renal calcium reabsorption, leading eventually to an increased calcium excretion (Conigrave et al....
Aberrant protein aggregation is a hallmark of many age-related diseases, yet little is known about whether proteins aggregate with age in a non-disease setting. Using a systematic proteomics approach, we identified several hundred proteins that become mo
Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave. J Gerontol A Biol Sci Med Sci. 2009; 64A: 167-170. doi: ... Morimot,I Richard,Cuervo,... - 《Journals of Gerontology》 被引量: 225发表: 2009年 Chaperone-mediated autophagy in aging and neurodegenerati...
Proteins unadjusted (A, B) and adjusted (C, D) for age and sex were included for comparison. Linear predictors were selected based on results of stepAIC models of adjusted data for EOAD (E) and LOAD (F), with the best model based on highest AICs relative to model complexity plotted ...
We are now entering a new era in protein sequence and structure annotation, with hundreds of millions of predicted protein structures made available through the AlphaFold database1. These models cover nearly all proteins that are known, including those c
A new generation of SARS-CoV-2 vaccines targeting the Omicron variant are urgently needed. Here, we developed a subunit vaccine named RBD-HR/trimer by directly linking the sequence of RBD derived from the Delta variant (containing L452R and T478K) and HR1 and HR2 in SARS-CoV-2 S2 ...