RNA is a single-stranded polynucleotide containing the nucleosides adenosine, guanosine, cytosine, and uridine. Roughly one-third to one-half of the nucleotides are engaged in intrastrand hydrogen bonds, with single-stranded segments interspersed between double-stranded regions that may contain up to ...
Methods of RNA and protein synthesisdoi:EP1279736 A1Sakanyan VeharySnapyan MarinaGhochikyan AnahitLecocq Françoise-MichèleEP
PROTEIN SYNTHESIS = CELL CONTROL 12-3 RNA and Protein Synthesis
Programmable approaches to sense and respond to the presence of specific RNAs in biological systems have broad applications in research, diagnostics, and therapeutics. Here we engineer a programmable RNA-sensing technology, reprogrammable ADAR sensors (RADARS), which harnesses RNA editing by adenosine dea...
T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino acids. Protein synthesis is an energy- and
Remarkably, visualization of the most mutated 7TM positions on a representative GPCR 3D structure revealed that most mutations occur in “hotspot structural motifs” rather than being randomly distributed (Fig. 3 and Table S3). This includes frequent mutations in the DRY arginine motif, which is ...
Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normox
On the other hand, we identified two proteins related to mRNA processing: U2 small nuclear ribonucleoprotein A involved in intron recognition during pre-mRNA splicing in plants [95] and RNA-binding protein 1-like isoform X2, an alternative splicing (AS) regulator that binds to specific mRNAs ...
Electrochemiluminescence (ECL) is a light-emitting process triggered by the high energy redox between electrochemically oxidized and reduced luminophores or some coreactive intermediate radicals, representing a blooming hot topic over decades with a wide
Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal can