The protein synthesis has three stages, which include polypeptide chain initiation, chain elongation, and chain termination. The main features of the initiation step are binding of mRNA to the ribosome, selection of the initiation codon, and binding of the charged tRNA bearing the first amino acid...
【1】Protein synthesis is anelaborateprocess starting from the nucleus and ending in the cytoplasm. 蛋白质合成是一个从在细胞核中开始到在细胞质中结束的复杂过程。【elaborate 精心制作的】 【2】Protein synthesis is referred t...
The rates of both protein and RNA synthesis (i.e., specific activities of protein and RNA) were higher in the dystrophic muscle, but when they were expressed on a DNA basis, the total protein synthesis per cell was the same as that of normal muscle and the total RNA synthesis per cell...
32. Tuorto, F. et al. RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Nature structural & molecular biology 19, 900-905 (2012). 33. Tuorto, F. et al. The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoies...
32. Tuorto, F. et al. RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Nature structural & molecular biology 19, 900-905 (2012). 33. Tuorto, F. et al. The tRNA methyltra...
1.Pan, Y., Lu, J., Feng, X. et al. Gelation of cytoplasmic expanded CAG RNA repeats suppresses global protein synthesis. Nat Chem Biol (2023). https://doi.org/10.1038/s41589-023-01384-5 运营/排版:何晨龙 由DeepTech 携手《麻省理工科技评论》重磅推出的《科技之巅:全球突破性技术创新与未来...
(a) Effect of sensor-target hybridization on protein production is analyzed by Western blot. PPIB protein levels are shown in response to RADARS hybridization and GAPDH is used as a normalizing protein control. b) qPCR detected gene expression fold change of four dsRNA responsive genes (IFNb, ...
(FTD). Common mechanisms underlying aging and neurodegeneration involve dysregulated RNA metabolism and genome instability. Altered gene expression and proteinsynthesis has been shown to be associated with aging, as well as age-associated neurodegeneration. Protein abnormalities and inclusion bodies are ...
have been identified, Y and analogous with epigenetic terminology, have been m6A RNA methylation dynamically G designated “writers,” “erasers,” and “readers.” Such regulates the epitranscriptome 6 O m6A RNA methylation (N -methyladenosine)...
DNA:DNA:RNA triplexes that are formed through Hoogsteen base-pairing of the RNA in the major groove of the DNA duplex have been observed in vitro, but the extent to which these interactions occur in cells and how they impact cellular functions remains elusive. Using a combination of bioinforma...