(2)作者在文中综述了PROTACs技术发展的里程碑,并介绍了近年来PROTACs技术在靶向蛋白降解(TPD)方面的应用情况;随后,作者也对于拓展PROTAC工具箱以及其在治疗领域中的应用前景进行了讨论和展望。Ke Li. et al. PROTACs: past, present and future. Chemical Society Reviews. 2022DOI: 10.1039/d2cs00193dhttps://pu...
(protacs)—past, present and future. drug discov. today technol. 31, 15–27. schneekloth, a.r. et al. (2008) targeted intracellular protein degradation induced by a small molecule: en route to chemical proteomics. bioorganic med. chem. lett. 18, 5...
PROteolysis TArgeting Chimeras (PROTACs)—past, present and future. Drug Discov Today: Technol. 2019;31:15–27. Article PubMed Google Scholar Li R, Liu M, Yang Z, Li J, Gao Y, Tan R. Proteolysis-Targeting Chimeras (PROTACs) in Cancer Therapy Present and Future. Molecules (Basel, ...
[12]Mariell Pettersson et al. PROteolysis TArgeting Chimeras (PROTACs) — Past, present andfuture. Drug Discovery Today:Technologies(2019). [13]Jan Krönke et al. Lenalidomide Causes Selective Degradation of IKZF1 and IK...
Pettersson M, Crews CM (2019) PROteolysis TArgeting chimeras (PROTACs)—past, present and future. Drug Discov Today Technol 31:15–27 Article PubMed PubMed Central Google Scholar Pfaff P, Samarasinghe KT, Crews CM, Carreira EM (2019) Reversible spatiotemporal control of induced protein degradati...
M. PROteolysis TArgeting Chimeras (PROTACs)—past, present and future. Drug Discov. Today Technol. 31, 15–27 (2019). Article PubMed PubMed Central Google Scholar Zengerle, M., Chan, K.-H. & Ciulli, A. Selective small molecule induced degradation of the BET bromodomain protein BRD4. ...
PROteolysis TArgeting Chimeras (PROTACs) - past, present and future Drug discovery today. Technologies, 31 (2019), pp. 15-27 View PDFView articleView in ScopusGoogle Scholar [37] M.J. Bond, C.M. Crews Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targe...
M. PROTAC targeted protein degraders: the past is prologue. Nat. Rev. Drug Discov. 21, 181–200 (2022). Article PubMed PubMed Central Google Scholar Li, K. & Crews, C. M. PROTACs: past, present and future. Chem. Soc. Rev. 51, 5214–5236 (2022). Article CAS PubMed PubMed ...
PROteolysis TArgeting Chimeras (PROTACs) - Past, present and future Drug Discov Today Technol, 31 (2019), pp. 15-27, 10.1016/j.ddtec.2019.01.002 View PDFView articleView in ScopusGoogle Scholar [54] M. Kostic, L.H. Jones Critical Assessment of Targeted Protein Degradation as a Research To...
M. PROTAC targeted protein degraders: the past is prologue. Nat. Rev. Drug Discov. 21, 181–200 (2022). Article PubMed PubMed Central Google Scholar Li, K. & Crews, C. M. PROTACs: past, present and future. Chem. Soc. Rev. 51, 5214–5236 (2022). Article CAS PubMed PubMed ...