Here, we address important milestones in the development of the PROTAC technology, as well as emphasize key findings from this previous year and highlight future directions of this promising drug discovery modality.doi:10.1016/j.ddtec.2019.01.002Pettersson, Mariell...
(protacs)—past, present and future. drug discov. today technol. 31, 15–27. schneekloth, a.r. et al. (2008) targeted intracellular protein degradation induced by a small molecule: en route to chemical proteomics. bioorganic med. chem. lett. 18, 5...
[12]Mariell Pettersson et al. PROteolysis TArgeting Chimeras (PROTACs) — Past, present andfuture. Drug Discovery Today:Technologies(2019). [13]Jan Krönke et al. Lenalidomide Causes Selective Degradation of IKZF1 and IK...
2019年3月20日,Nature发文称,基于蛋白水解靶向嵌合体(Proteolysis-TargetingChimeras,PROTACs)技术的蛋白降解剂可能将成为下一个重磅药物。 蛋白降解剂首次进入专利文献是在1999年,当时来自生物技术公司Proteinix的研究人员John Kenten和Steven Roberts提交了一项小分子化合物的专利(查看专利:go.nature.com/2vyjf9l),该化...
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