Chitkara College of Pharmacy, Chitkara University, Punjab, IndiaSingh, ManjinderChitkara College of Pharmacy, Chitkara University, Punjab, IndiaSingh, TanveerDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A &M University Health Science Centre, Bryan, USASingh, ...
Senescent cells accumulate throughout the body with advanced age, diseases and chronic conditions. They negatively impact health and function of multiple systems, including the central nervous system (CNS). Therapies that target senescent cells, broadly
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. In the 20 years since the concept of a proteolysis-targeting chimera (PROTAC) molecule...
Proteolysis-targeting chimeras (PROTACs) are an emerging drug modality that may offer new opportunities to circumvent some of the limitations associated with traditional small-molecule therapeutics. By analogy with the concept of the 'druggable genome', the question arises as to which potential drug ta...
Our understanding of the mechanisms that control this phenotypic switch has also expanded, revealing the crucial role of reprogramming factors and chromatin remodelling. Further deciphering the molecular basis of tumour cell plasticity has the potential to contribute to new therapeutic strategies which, ...
In addition, we also introduce recent developments of the PROTAC technology such as homo-PROTACs. The outstanding advantages over traditional small-molecule drugs and the promising preclinical data suggest that small-molecule PROTAC technology has the potential to greatly promote the development of ...
Although mostly explored as a transgenic expressed vector in cells, the anticancer profile of Omomyc played an important part in establishing the therapeutic potential of c-Myc inhibition. Fig. 3 Proposed mechanisms of Omomyc. Studies have suggested that: 1. Omomyc (Orange) homodimer blocks c-Myc...
It is reported that BRD4-targeting PROTACs has potential therapeutic benefit for hematological malignancies including multiple myeloma28, secondary AML29, lymphoma30,31, and castration-resistant prostate cancer32 in preclinical studies. However, the large molecular weight and low water solubility of ARV-...
aberrantly activated cytokine signaling boosted HLA-G and PD-L1 expression to impair NK cells cytotoxicity, leading to trastuzumab resistance, whereby the immense therapeutic potential of HLA-G-blocking antibody combined with anti-PD-1/PD-L1 antibody in trastuzumab-resistant breast cancer patients was ...
Tumor microenvironment-mediated immune resistance: role of immune cells CAF-TAM crosstalk-mediated immune resistance CAFs and immune microenvironment regulation CAFs, primarily generated by the trans-differentiation of resident fibroblasts, have emerged as critical therapeutic targets [10,112,113]. Although ...