Men with locally advanced cancers are at higher risk of death from prostate cancer (than those with pT1-2) and so require treatment if Metastatic disease Metastatic disease may involve spread to the lymph nodes, bones or (less commonly) other organs (Figure 4, Figure 5). Androgen deprivation...
I believe it still has a place. Prostate cancer spreads easily to the bones, and it is not uncommon for undiagnosedprostate cancerto manifest as back pain when it has spread to the vertebrae. If this is suspected, then positive findings on rectal examination may lead to a more timely diagno...
The cancer cells grow and begin to multiply uncontrollably. They initially spread to the surrounding tissues to form a tumor nodule that is able to grow outside the prostate (extracapsular extension) or be located within the prostate. Usually, this type of cancer metastasizes to the bones and...
Treatment options for prostate cancer include: Hormone therapy – where the prostate is ‘starved’ of testosterone in order to try to slow down the spread of cancerous cells from your prostate Surgery – where the prostate is removed Brachytherapy – where radioactive seeds are implanted in the...
My Dad is suffering prostate cancer Stage 4. It had spread to bone, liver and some other area. He is 77.5 years old. He had received: Hormone therapy Chemotherapy Lutetium LU 177 But his cancer is still spreading. My Dad is a bit weak now, he lost his appetite and is also anaemic....
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Prostate cancer is the second commonest male cancer worldwide, [1] and the most commonly diagnosed cancer in men in the UK, with an estimated 47,151 diagnoses in 2015 [2]. Generally, most prostate cancers are slow growing, but can metastasize to the bones, lungs, and brain. Worldwide,...
The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical...
We would both like to say a massive thank you to everyone who has followed this blog, encouraged and helped us along the way, and a special thanks to those who donated to Prostate Cancer UK. Knowing we had such amazing support made a huge difference when things got tough. We ended up ...
The unique microenvironment of the prostate plays a crucial role in the development and progression of prostate cancer (PCa). We examined the effects of cancer-associated fibroblasts (CAFs) on PCa progression using patient-derived fibroblast primary cult