CANCER researchCANCER cellsMultiple cancer cell types are found in prostate tumors. They are either luminal-like adenocarcinoma or less luminal-like and more stem-like non-adenocarcinoma and small cell carcinoma. These types are lineage related through differentiation. Loss of ca...
Prostate tumor heterogeneity is a major factor in disease management. Heterogeneity could be due to multiple cancer cell types with distinct gene expression. Of clinical importance is the so-called cancer stem cell type. Cell type-specific transcriptomes
Prostate cancer is the second most common malignancy in men worldwide and consists of a mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organo...
cancer may originate in the central or transitional zone of the prostate gland but these may be associated with rare types of prostate cancer like small cell carcinoma, transitional cell carcinoma or a
circles are used for orientation, and lack spatial barcodes. The ST procedure yields matrices with read counts for every gene in every spot, which are then decomposed by factor analysis resulting in a set of factors (“cell types”), each comprising one activity map and one expression profile...
Abstract: Novel human prostate cancer-associated neuroendocrine (NE)-like cell lines are provided that were derived via a process that resembles clinical androgen ablation therapy for advanced prostate cancer. Representative Image: Inventors: Lin, Ming-fong (Omaha, NE) ...
Eph receptor (Eph) and ephrin signaling can play central roles in prostate cancer and other cancer types. Exposed to ephrin-A1 PC3 prostate cancer cells alter adhesion to extracellular matrix (ECM) proteins. However, whether PC3 cells increase or reduce adhesion, and by which mechanisms they chan...
Prostate cancer, disease characterized by uncontrolled growth of cells within the prostate gland. Prostate cancer is a frequently diagnosed cancer among males. Learn more about the causes, symptoms, and treatment of prostate cancer.
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intuitive and comprehensive understanding of the heterogeneity of prostate cancer. Tumour-associated ep...
prostate cancer, we first visualized the phenotype of serum-containing and serum-deprived prostate cancer cell lines, and the phenotype of serum-deprived cell lines stimulated with hydrogen peroxide (H2O2), our model of oxidative stress34,35,36. Serum-containing cells in each prostate cancer cell ...