Purpose of Review This review will examine the taxonomy of PCa subclasses across disease states, explore the relationship among specific alterations, and highlight current clinical relevance. Recent Findings Prostate cancer (PCa) is driven by multiple genomic alterations, with distinct patterns and clinic...
Unusual subtypes of prostate cancer. Mod Pathol. 2004;17:316–27.Grignon DJ. Unusual subtypes of prostate cancer. Mod Pathol 2004; 17(3): 316-27.Rhee;DJ.Unusual subtypes of prostate cancer.0Unusual subtypes of prostate cancer. David J Grignon. Modern Pathology . 2004...
Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) has a high detection rate of prostate cancer and can predict response to systemic therapies including, chemotherapy and ${ }^{177} \mathrm{Lu}$-PSMA therapy. Automated tumor quantification and subt...
Trends in Prostate Cancer Survival in Sweden, 1960 Through 1988: Evidence of Increasing Diagnosis of Nonlethal Tumors The incidence of prostate cancer has increased during the past 30 years but has been paralleled by increases in survival rates from this disease, despite t... H Fred,H Lars,Joha...
Neuroendocrine prostate cancer (NEPC) encompasses various clinical contexts, ranging from the de novo presentation of small cell prostatic carcinoma to a treatment-emergent transformed phenotype that arises from typical adenocarcinoma of the prostate. The development of resistance to potent androgen receptor...
Luminal B subtype as a predictive biomarker of docetaxel benefit for newly diagnosed metastatic hormone sensitive prostate cancer (mHSPC): a correlative study of E3805 CHAARTED. Presented at: ASCO Annual Meeting; 2019; Chicago, IL. 14. Cerami E, Gao J, Dogrusoz U, et al. The ...
The phosphoinositide 3-kinase (PI3K) pathway is one of the most altered oncogenic pathways in human cancer1,2. In hormone-regulated cancers such as prostate and breast cancer, activation of the PI3K pathway is often driven by mutations/amplification/overexpression ofPIK3CA/PIK3CB, or loss of the...
Identification of molecular subtypes and prognostic index. (A) heatmap showing all subtypes of prostate cancer patients in TCGA database; (B) Kaplan–Meier curve showing survival differences of subtype 1 and subtype 2 in TCGA database; (C) heatmap showing two subtypes of prostate cancer patients...
Lisa A. Carey, MD, Professor of Medicine, University of North Carolina at Chapel Hill, discusses assays and intrinsic subtypes of breast cancer.Lisa A. Carey, MD, Professor of Medicine, University of North Carolina at Chapel Hill, discusses assays and intrinsic subtypes of breast cancer....
Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences in the molecular pathology of otherwise indis