Prostaglandin E2 (PGE2) function in pregnancy – New perspectives for the putatively pro‐quiescent downstream target RGS2Background The prostaglandin pathway plays an important, but complex, role in human labour. Targeting this pathway to treat preterm labour is not wholly effective nor fully safe....
Prostaglandin (PG) E2 is a bioactive lipid that plays protective roles in the lung, particularly during allergic inflammation. Objective We set out to investigate how PGE2 regulates human ILC2 function. Methods The effects of PGE2 on human ILC2 proliferation and intracellular cytokine and ...
Prostaglandin E2 breaks down pericyte–endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras Abstract A close association between pericytes and endothelial cells (ECs) is crucial to the stability and function of capillary blood vessels and...
we isolated the interstitial fluid of several tissues and analyzed the fluid using untargeted metabolomics. The analysis revealed a group of metabolites uniquely present in the small intestine, including prostaglandin E2(PGE2) (Fig.3b, c). PGE2signaling is constitutive in the gut ...
Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension Biochem. Pharmacol. (2005) Y. Sugimoto et al. Prostaglandin E receptors J. Biol. Chem. (2007) S. Ayabe et al. Prostaglandin E2 induces contraction of liver myofibroblasts by activating...
There is periparturitional increase of prostaglandin E2 (PGE2) in the plasma and amniotic fluid of humans. PGE2 increases uterine contractions and also increases uterine blood flow to sustain the contractions. A question arises as to what role PGE2 plays in human placental circulation. It may r...
Prostaglandin E2 Is a Major Inhibitor of Dendritic Cell Maturation and Function in Ixodes scapularis Saliva Tick saliva is thought to contain a number of molecules that prevent host immune and inflammatory responses. In this study, the effects of Ixodes scapulari... A Sá-Nunes,A Bafica,DA Luc...
Derivatization of drugs containing a carbonyl function: aldehydes and ketones The ethylene ketal derivative of prostaglandin E2 (dinoprostone) possesses much improved solid-state stability (see Chapter 39). Functionalized spirothiazolidines of hydrocortisone and hydrocortisone 21-acetate (Fig. 33.6), prepare...
Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection. Chen JH,Perry CJ,Tsui YC,et al. Nature Medicine . 2015Chen, J.H.; Perry, C.J.; Tsui, Y.C.; Staron, M.M.; Parish, I.A.; Dominguez, C.X.; Rosenberg...
Limited data are available on the mechanisms that constrain the function of regulatory populations of T cells. Prostaglandin E2 (PGE2) is an endogenous membrane phospholipid metabolite that has important immunomodulatory effects on T cell function. Our previous microarray data indicated that E prostanoid...