Using single-cell RNA sequencing and oligo-tagged antibody staining, we resolved the transcriptional and metabolic adaptation of CD8+T cells to the intestinal microenvironment. Upon sensing prostaglandin E2(PGE2) in the gut tissue, CD8+T cells decreased their mitochondrial content. PGE2induced mitochon...
Prostaglandinsare another major class of important intrafollicular signaling agents critical for ovulation. The predominantprostaglandinproduced bygranulosa cellsisprostaglandin E2, (PGE2) which interacts with the PGE2-receptor (EP-2) (Fig. 3) to induce cumulus gene expression critical for ovulation[142,...
The present invention also provides an application of the substance capable of upregulating signaling activities of PGE2 receptors EP4 and/or EP2 signaling pathways in preparing a drug for regulating vascular remodeling in a subject. The present invention also provides a preparation for regulating ...
Protein kinase C activation reduces microglial cyclic AMP response to prostaglandin E2 by interfering with EP2 receptors J Neurochem, 74 (2000), pp. 400-405 View in ScopusGoogle Scholar 44 K. Wilkinson, J.D. Boyd, M. Glicksman, K.J. Moore, J. El Khoury A high content drug screen identi...
The class of compounds useful in this method of treatment is represented by Formula I below: ##STR1收藏 引用 批量引用 报错 分享 文库来源 其他来源 求助全文 Prostaglandin synthase inhibitors 优质文献 相似文献 参考文献Conversion of Prostaglandin G/H Synthase-1 into an Enzyme Sensitive to PGHS-2-...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook Prostaglandin analogue (redirected fromProstaglandin analogs) A class of drugs that are similar in structure and function to prostaglandin. Mentioned in:Glaucoma ...
Prostacyclin and related drugs have been used in the clinical treatment of PAH. Other prostaglandins also have the potential to treat PAH. This review provides ideas for the treatment of PAH and the discovery of new drug targets. Similar content being viewed by others ...
World Health Organization (WHO)Alprostadil, a prostaglandin with vasodilating and platelet antiaggregatory activity, was introduced in 1984 for the treatment of chronic arterial obstruction. Intravenous administration of the drug has been associated with adverse effects that have sometimes been severe. The...
118 Meclofenamate has a high incidence of GI toxicity and is also not a first-line drug. It is well absorbed orally; peak plasma levels are reached after 2 hours, with a half-life of about 4 to 6 hours. Naphthylalkanones This newer class of NSAIDs is most noted for its nonacidic ...
alarmins; airway epithelium; aspirin-exacerbated respiratory disease; asthma; innate immunity; mast cells; prostaglandin E2; prostaglandin D21. Introduction Aspirin-exacerbated respiratory disease (AERD), known in Europe as nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD...