I am interested in the proportion of the effect from X to Y which is mediated through M. My Mplus model: MODEL: Y on X M; M on X; model indirect: Y IND X; gives a total effect of 0.386 and total indirect of 0.149, so I get a proportion of 0.149/0.386 = 38.6% As ...
To overcome these difficulties, we propose a new surrogacy measure, the proportion of treatment effect mediated by candidate surrogate endpoints (PMS), based on the decomposition of the treatment effect into direct, indirect, and interaction associations mediated by candidate surrogate endpoints. In ...
Maternal genetic risk of type 2 diabetes (T2D) has been associated with fetal growth, but the influence of genetic ancestry is not yet fully understood. We aimed to investigate the influence of genetic distance (GD) and genetic ancestry proportion (GAP)
the proportion of TNF-α+ γδT cells was negatively correlated with the levels of ALT and AST.Conclusion Although the proportion of total γδT cells in peripheral blood of HBV-ACLF patients decreases,the ability of the γδT cells in producing IFN-γ,TNF-α and IL-17 is enhanced,which...
The proportion of something is the number of observations that meet a certain criterion, divided by the total number of observations. For example, the proportion of males in the population of Americans is the number of American males divided by the numbe
Maternal Placental Blood Flow Is Reduced in Proportion to Reduction in Uterine Driving pressure1 MARY R. LAIRD, J. JOB FABER, AND NANCY D. BINDER Departments of Pediatrics and Physiology, Oregon Health Sciences University, Portland, Oregon 97201-3098 The relationship between uterine driving pressure...
bacterial genera. Asterisks represent significant differences of slopes from the 1:1 line (two-sided unadjustedt-tests; C:Controlt287= −0.60 ± 0.06 (std error),p = 0.548, effect-sizer= −0.0007; C + N:Controlt489 = 2.42 ± 0.06,p = 0.016, effect-sizer=...
Methylprednisolone is widely used to improve immune suppression in transplanted patients threatened by acute rejection. Recently, we showed that the suppressive activity of a Treg cell population depends decisively on their percentage of highly suppressive HLA-DRhigh+-Treg cells, which are strongly reduce...
With that said, the exploitation of the anti-oxidative stress mechanism of Sr-doped implants may be the key to realize its anti-osteoporosis potential. That being said, however, Sr is demonstrated to be heavily dose-dependent. A low dose of Sr is proven to be conducive to osteogenesis and ...
In rats, a shift from somatotroph dominance to lactotroph dominance during pregnancy and lactation is well reported. Somatotroph to lactotroph transdifferentiation and increased lactotroph mitotic activity are believed to account for this and associated