Propionyl CoA carboxylase is a dodecameric enzyme consisting of multiple copies of alpha and beta subunits encoded by the PCCA and PCCB genes. Mutations in either PCCA or PCCB can cause the disease. PA is categorized as a rare disease and accessing patients' cells to study the disease has ...
propionyl-CoA carboxylase Propionyl-CoA Carboxylase, Alpha Subunit Propionyl-CoA Carboxylase, Beta Subunit propionylglycine Propios Propithecus propitiable propitiate propitiated propitiates propitiating propitiatingly propitiation propitiations propitiatious propitiative propitiatively propitiator propitiatorily...
Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity Biochemistry, 43 (2004), pp. 14027-14036 View in ScopusGoogle Scholar [13] T. Ohura, J.P. Kraus, L.E. Rosenberg Unequal synthesis and differential degradation of propionyl CoA car...
Propionic acidemia (PA) is an autosomal recessive metabolic liver disease caused by defects in propionyl CoA carboxylase. Propionyl CoA carboxylase is a dodecameric enzyme consisting of multiple copies of alpha and beta subunits encoded by the PCCA and PCCB genes. Mutations in either PCCA or PCCB ...
The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit...
PCCA Antibody is a Rabbit Polyclonal Antibody against PCCA.应用类型 WB免疫原 PCCA来源宿主 兔反应性 人,小鼠,大鼠保存建议 建议收到该Propionyl-CoA Carboxylase Alpha Subunit (PCCA) Antibody产品后,储存温度为-20°C。避免重复冻融其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白...
The identi—cation of mutations in the PCCA gene (encoding the a-subunit) has progressed recently, revealing the molecular heter- ogeneity of the disease (Campeau et al 1999; Richard et al 1997). In this study, we have identi—ed —ve missense mutations and one deletion in the PCCA ...
this SNP is a significant expression quantitative locus (eQTL) for a neighboring gene, PCCB, encoding the Propionyl-CoA carboxylase beta subunit, in vascular tissues and whole blood, with the common allele rs667920_T being linked to increased expression of PCCB, circulating lipids and CAD, sugges...
glycerol kinase; GPD1, glycerol-3-phosphate dehydrogenase 1; GPD2, glycerol -3-phosphate dehydrogenase 2; ACSS3, acyl CoA synthetase short chain family member 3; PCCA,propionyl CoA carboxylasealpha; PCCB,propionyl CoA carboxylasebeta; MCEE, methylmalonyl CoA epimerase; MUT, methylmalonyl CoA mutase...
Tahara T, Kraus JP, Rosenberg LE (1990) An unusual insertion/deletion in the gene encoding the β-subunit of propionyl-CoA carboxylase is a frequent mutation in Caucasian propionic acidemia. Proc Natl Acad Sci USA 87:1372–1376Tahara T, Kraus JP, Rosenberg LE (1990) An unusual insertion/...