These mustards were the prototype of a variety of compounds tested as anticancer drugs, with very different chemical structures (Figure 10.1), but having in common that they functioned as DNA alkylating agents under physiological conditions and possessed mutagenic potential 4 ....
Mechanical properties of tumor cytoskeleton are extremely vital for any phases of cancer, especially in tumor invasion and metastasis. However, in current category of anticancer drugs, the cytoskeleton-targeting drugs are limited and its role in tumor progression is unclear. Here, we present the mech...
However, anticancer activity of SBS was observed more efficient against MCF-7 than that against MCF-7/MX cells. SBS is suggested to be considered as one of the prospective anticancer drugs to treat human breast carcinoma. More investigations especially in vivo studies are strongly recommended to ...
Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity Article Open access 15 June 2022 4-Furanylvinylquinoline derivative as a new scaffold for the design of oxidative stress initiator and glucose transporter inhibitor drugs Article Open...
Ideally, anticancer drugs should specifically target cancer cells without any toxic effect against normal cells but, unfortunately, most of the available anticancer drugs display severe side effects. Moreover, development of multidrug resistance by cancer cells4,5 makes the situation even more critical....
Traditional Chinese medicines have been recently recognized as a new source of anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy and to ameliorate the side effects of cancer chemotherapies however their healing mechanisms are still largely unknown. Scutellaria baicalensis...
A recent advance in the synthesis of hypocrellin congeners results in the production of two amino-substituted h... YY He,LJ Jiang - 《Free Radical Biology & Medicine》 被引量: 45发表: 2000年 Characterization of anticancer hypocrellin A encapsulated with silica nanoparticles Hypocrellins, natural ...
We have investigated the comparative initial DNA binding properties of 7 platinum-based anticancer drugs: 5 cis -oriented compounds, cisplatin, tetraplatin... KJ Mellish,CFJ Barnard,BA Murrer,... - 《International Journal of Cancer》 被引量: 50发表: 2010年 Drug-binding and other physicochemical...
Sensitizing activities of nitric oxide donors for cancer resistance to anticancer therapeutic drugs. Biochemical Pharmacol. 2020;176:113913. Article CAS Google Scholar Boden WE, Padala SK, Cabral KP, Buschmann IR, Sidhu MS. Role of short-acting nitroglycerin in the management of ischemic heart ...
Some favourable properties of 1D materials, include a larger/higher relative surface area, and tuneable oxidative stress and catalytic ability22,36,39. Within biological systems, 1D materials have been investigated for potential anticancer applications40 and other biomedical application41,42. 2D materials...