Promyelocytic leukemia zinc-finger inductionsigns mesenchymal stem cell commitment: identification of a key marker for stemnessmaintenance?. Djouad F,Tejedor G,Toupet K,et al. Stem Cell Res Ther . 2014Djouad, F., Tejedor, G., Toupet, K., Maumus, M., Bony, C., Blangy, A., Chuchana...
The human promyelocytic leukemia zinc finger gene is regulated by the Evi-1 oncoprotein and a novel guanine-rich site binding protein 相关内容 a虽然我们从未见过、交流过,甚至不知道对方是个怎么样的一个人,但是我对你并不陌生,想与你建成一座可以交流的对话框,更想认识你,做你心底最心爱的宝贝!期待你...
Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor a locus due to a variant t(11,17) translocation in acute promyelocytic leukemia. EMBO J. 12, 1161–1167 (1993). Article CAS PubMed PubMed Central Google Scholar Licht, J. D. et al. Clinical and ...
Acute promyelocytic leukemia is associated with chromosomal translocations that involve the RARalpha gene and several distinct loci producing a variety of fusion proteins. One such fusion partner is promyelocytic leukemia zinc-finger gene (PLZF), a member of the POK (POZ and Kruppel) family of trans...
et al. ( 1998 ) Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukemia. Nature , 391 , 815 –818.Grignani F, De Matteis S, Nervi C, et al. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic ...
Acute promyelocytic leukemia (APL) is designated M3 in the French-American-British (FAB) classification. Because of its unique clinical features and unique response to certain differentiation-inducing agents, and because of our advanced understanding of the molecular biology and treatment of this leukemi...
Acute promyelocytic leukemia (APL) is characterized by the accumulation of promyelocytes in bone marrow. More than 95% of patients with this disease belong to typical APL, which express PML-RARA and are sensitive to differentiation induction therapy cont
Invariably, APL leukemic cells harbor chromosomal translocations involving the retinoic acid receptor α ( RARα ) gene on chromosome 17 (Table 1 ), which may be fused to one of five possible partner genes: promyelocytic leukemia ( PML ), promyelocytic leukemia zinc finger ( PLZF ), ...
Acute promyelocytic leukemia (APL) cells exhibit disrupted regulation of cell death and differentiation, and therefore the fate of these leukemic cells is unclear. Here, we provide the first evidence that a small percentage of APL cells undergo a novel c
Although the mixed lineage leukemia 5 (MLL5) gene has prognostic implications in acute promyelocyte leukemia (APL), the underlying mechanism remains to be elucidated. Here, we demonstrate the critical role exerted by MLL5 in APL regarding cell proliferat