The anti-tumor effect of perforin was analyzed using prostate cancer (PC) PC-3 cells in which perforin expression was controlled by Tet-on system (PC-3PRF cells). Liposomes encapsulating PSA promoter-driven perforin expression vector (pLipo) were constructed for its specific expression in PC. ...
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans Nature, 477 (2011), pp. 99-102 CrossrefGoogle Scholar 31 R.I. Mahato, K. Kawabata, Y. Takakura, M. Hashida In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes J. Drug Targ...
OriginalArticles Liposomalinsulinpromoter–thymidinekinasegenetherapyfollowed byganciclovireffectivelyablateshumanpancreaticcancerinmice JamesX.Wu a ,Shi-HeLiu a ,JohnJ.Nemunaitis b ,F.CharlesBrunicardi a, * a DavidGeffenSchoolofMedicine,UCLA,LosAngeles,CA,USA b MaryCrowleyCancerResearchCenters,Dallas,TX...
23 October 2015 Transrepression in Luminal Cancer Cells Madhu Mahankali, Terry Farkaly, Shimpi Bedi, Heather A. Hostetler† & Julian Gomez-Cambronero The expression of the epidermal growth factor receptor (EGFR) is highly regulated in normal cells, whereas some cancer cells have hi...
6.The pharmaceutical composition of claim 5, which is used in the treatment of cancers. 7.The pharmaceutical composition of claim 6, wherein the cancer is selected from the group consisting of myeloid lymphomas, hepatocellular carcinoma, hepatoblastoma, rhabdomyosarcoma, esophageal carcinoma, thyroid ca...
1. A method of detecting the presence of a cancer correlated with the presence of Her-2/neu promoter binding factor, in a subject comprising determining the presence of a detectable amount of Her-2/neu promoter binding factor in a biological sample from the subject, the presence of a detecta...
After inoculation with the tumor, HVJliposomes containing the AFPTK1 plasmid vector were injected into the portal vein via the splenic hilum, followed by GCV treatment. This gene therapy significantly inhibited the growth of tumors in the liver and markedly improved survival. Three injections of the...
Furthermore, to elucidate the advantages of using liposomes as a gene carrier, we screened more than 20 liposome preparations in this study. The 5′ upstream region of PSA gene (PSARPSAP) was conjugated to either the chloramphenicol acetyltransferase (CAT) gene or herpes simplex virus thymidine ...
Transactivation of the metallothionein promoter in cisplatin resistant cancer cells: a specific gene therapy strategy. VandierD,CalvezV,Massade L,et al. Journal of the National Cancer Institute . 2000VandierD,CalvezV,Massade L,et al.Transactivation of the metallothionein promoter in cisplatin ...
Keywords Colorectal cancerCarcinoembryonic antigenGene therapyLiposomesInterferonsLuciferase genePURPOSE: This study was designed to characterize the mechanisms regulating the expression of the human carcinoembryonic antigen promoter (pCEA), in terms of tissue-specific targeting for gene therapy. The promoter ...