hyperinsulinemia, hepatic steatosis) by 10 weeks (40). These obese mice, however, have only a mild, controlled elevation in blood glucose and model the prediabetic state, providing a model of obesity that is not confounded by diabetes. Here, we identified 1,723 unique acetyl isoforms, 1,601...
2.3. Liver Analysis For histology, paraffin embedded sections (4 µm thick) stained with hematoxylin and eosin (H & E) of 10% formalin-fixed samples were evaluated. The obesity-induced liver damage scoring system was used as follows; steatosis (0–3), lobular inflammation (0–3), and he...