HEPATIC STEATOSIS INDEX IS INDEPENDENTLY RELATED TO HYPERTENSION MEDIATED ORGAN DAMAGE IN PATIENTS WITH FIRST DIAGNOSED AND NEVER TREATED ESSENTIAL HYPERTENSION AND SMOKING HABITObjective: Non-alcoholic fatty liver disease (NAFLD) is closely related to the metabolic syndrome, arterial hypertension and ...
However, during insulin resistance (IR), when insulin signalling is blunted and accompanied by hyperinsulinaemia, the promotion of hepatic DNL continues unabated and hepatic steatosis increases. Here, we show that WD40 repeat-containing protein 6 (WDR6) promotes hepatic DNL during IR. ...
4a). We therefore measured levels of FGF21, a hepatokine with a potent capacity to stimulate thermogenic activity23 and reduce hepatic steatosis24. Hepatic and plasma levels of FGF21 were significantly increased in DW rats (Extended Data Fig. 4b,c), suggesting that FGF21, which is ...
Of interest, we noted that simultaneously with the onset of transient hepatic steatosis upon PH, the resection-induced liver injury is most severe. In turn, a diminished liver injury was obvious in LRep1−/−, prob- ably due to a lower lipid load. Scientific Reports | (2018) 8:16858 ...
Define hepatic vein thrombosis. hepatic vein thrombosis synonyms, hepatic vein thrombosis pronunciation, hepatic vein thrombosis translation, English dictionary definition of hepatic vein thrombosis. n. pl. throm·bo·ses The formation, presence, or deve
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) that is characterized by hepatic inflammation and steatosis. Currently, limited data exist regarding the risk of NASH in transgender women and the treatment options for this particular population. The...
working to attenuate the effects ofoxidative stresson the liver and contain hepatic injury but paradoxically increasing levels offibrosisand severity of NASH[48]. A growing body of literature has also demonstrated the role ofKupffer cells, macrophages of the liver, in hepaticsteatosis, potentially thr...
steatosis and conducting mechanistic evaluations that revealed the repression ofde novolipogenesis as a common molecular pathway. The study also introduced FatTracer, a CRISPR screening platform designed to identify steatosis modulators and potential targets using APOB−/−and MTTP−/−organoids. ...
The elevation of TyG is considered an important factor in promoting the progression of non-alcoholic fatty liver disease (NAFLD), but its impact on the degree of liver steatosis remains unclear. This study aims to explore the relationship between TyG and TyG-related indices, such as triglyceride...
it is unknown whether IκBζ has a similar function in the development and progression of human NAFLD, albeit we observed the increase inNFKBIZin moderate steatosis. Further analysis is required to determine whether the induction of IκBζ in the liver of human NAFLD patients regulates the progre...