Spinal cord injury (SCI) results in significant neural damage and inhibition of axonal regeneration due to an imbalanced microenvironment. Extensive evidence supports the efficacy of mesenchymal stem cell (MSC) transplantation as a therapeutic approach for SCI. This review aims to present an overview o...
LDL was optimally managed < 70 mg/dl with a statin and subsequent addition of a PCSK9 inhibitor. Specifically, in terms of timeline, the patient was placed on atorvastatin 80 mg daily starting in 2009, and then evolocumab 140 mg every 2 weeks starting in 2018. 5 serial CCTAs were ...
Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid acc
All LC–MS/MS data were analyzed using MassHunter Quant (Agilent Technologies). No additional corrections were made for ion suppression; thus, concentrations are relative to the calibration curve and not absolute. Relative concentration of each compound was normalized to total protein amount and data ...
(f) Timeline of disease progression. Horizontal line indicates time from diagnosis to treatment. Tickmarks indicate point where sample was taken. (g) Number of genetic clusters, as estimated by PyClone. (FDRo 0.05), of which only 37/109 (34%) had a 410% allele frequency change (Figure ...
The cell cycle is at the center of cellular activities and is orchestrated by complex regulatory mechanisms, among which transcriptional regulation is one of the most important components. Alternative splicing dramatically expands the regulatory network
(at the time of article reporting) with binocular alignment. The data encompassed various parameters, including patient demographics (sex, age, place of origin), comprehensive medical history, onset timeline, etiological factors, visual acuity (LogMar visual acuity chart), and the enumeration of ...
Along this timeline, GPPM identifies an initial steep worsening of the EDSS that stabilizes after approximately 30 years of disease duration, suggesting its diminished utility in monitoring disease progression beyond this time. Conversely, it underscores the slower evolution of NBV across the disease ...
Post-translational modifications of proteins in malignant transformation and tumor maintenance of pancreatic ductal adenocarcinoma (PDAC) in the context of KRAS signaling remain poorly understood. Here, we use the KPC mouse model to examine the effect of palmitoylation on pancreatic cancer progression. ZD...
Graphic timeline of the experimental protocol is displayed in the supplemental material (Fig S9). Either AF-130 administration (Afferent Pharmaceuticals, San Mateo, California, USA), 30 mg/kg s.c. per day or vehicle (dimethylsulfoxide 99.9%, DMSO, Sigma-Aldrich, St. Louis, MO, USA) start...