“For decades, a variety of predictive approaches have been proposed and evaluated in terms of the predictive capability for Alzheimer’s disease and its precursor, mild cognitive impairment,” explained Dajiang Zhu, PhD, an associate professor in computer science and engineering a...
Alzheimer’s disease (AD) is a progressive neurogenerative disorder manifested by gradual memory loss and cognitive decline due to profound damage of cholinergic neurons. The neuropathological hallmarks of AD are intracellular deposits of neurofibrillary tangles (NFTs) and extracellular aggregates of amy...
Alzheimer's disease is the leading cause of dementia in the elderly, and there is no disease-modifying therapy yet available. Immunotherapy directed against the beta-amyloid peptide may be capable of slowing the rate of disease progression. Bapineuzu ...
Alzheimer’s disease (AD) is defined by the excessive accumulation of toxic peptides, such as beta amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFT). The risk factors associated with AD include genetic mutations, aging, insulin resistance, and oxidative stress. To date, several...
In spite of many years of research, our understanding of the molecular bases of Alzheimer’s disease (AD) is still incomplete, and the medical treatments available mainly target the disease symptoms and are hardly effective. Indeed, the modulation of a single target (e.g., β-secretase) has...
Nonetheless, studies in animal models of other neurodegenerative diseases, e.g., multiple sclerosis20 and Parkinson’s-95 and Alzheimer’s disease96 have shown that HFD results in more severe disease progression, demyelination, inflammation, death of neurons and brain atrophy. HFD results in up...
The latency to fall was measured with cut- offs of 60 s in the hanging wire test and of 300 s in the rotarod. Motor performance on these tests and weight were assessed in experimental mice three times every week from the age of 60 days until an end-stage point of the disease. Mice ...
Glioblastoma is the most common primary brain tumor and has a dismal prognosis. The development of central necrosis represents a tipping point in the evolution of these tumors that foreshadows aggressive expansion, swiftly leading to mortality. The onset of necrosis, severe hypoxia and associated radi...
disease prognosis [5]. Controlled inflammatory processes include specific immune responses—mainly linked with the maturation of antigen-presenting cells that promote tissue/organ healing. On the other hand, amplified, uncontrolled, or prolonged inflammation associated with immunosuppression is linked with ...
Vogel, J.W.; Young, A.L.; Oxtoby, N.P.; Smith, R.; Ossenkoppele, R.; Strandberg, O.T.; La Joie, R.; Aksman, L.M.; Grothe, M.J.; Iturria-Medina, Y.; et al. Four distinct trajectories of tau deposition identified in Alzheimer’s disease.Nat. Med.2021,27, 871–881....