Alzheimer’s disease (AD) is a progressive neurogenerative disorder manifested by gradual memory loss and cognitive decline due to profound damage of cholinergic neurons. The neuropathological hallmarks of AD are intracellular deposits of neurofibrillary tangles (NFTs) and extracellular aggregates of amy...
Pereira JB, Strandberg TO, Palmqvist S, Volpe G, van Westen D, Westman E et al (2018) Amyloid network topology characterizes the progression of Alzheimer's disease during the predementia stages. Cereb Cortex 28:340-349. https://doi.org/10.1093/cerco r/bhx294...
Nonetheless, studies in animal models of other neurodegenerative diseases, e.g., multiple sclerosis20 and Parkinson’s-95 and Alzheimer’s disease96 have shown that HFD results in more severe disease progression, demyelination, inflammation, death of neurons and brain atrophy. HFD results in up...
Although beta-amyloid (Aβ) positivity has shown to be associated with higher risk of progression to Alzheimer's disease (AD) in mild cognitive impairment (MCI), information on the time to conversion to manifest dementia cannot be readily deduced from this binary classification. Here, we assessed...
In spite of many years of research, our understanding of the molecular bases of Alzheimer’s disease (AD) is still incomplete, and the medical treatments available mainly target the disease symptoms and are hardly effective. Indeed, the modulation of a s
Journal of Alzheimer's Parkinsonism & Dementia Modeling Stages Mimic Alzheimer's Disease Induced by Different Doses of Aluminum in Rats: Focus on Progressi... A Ali,H Ahmed,K Abuelfoutouh 被引量: 0发表: 2016年 Relationship of aluminum to Alzheimer's disease. Alzheimer's disease is a ...
These findings suggest ephrin-A5 as a modifier of disease progression that might play a role in the later stages of the disease. Similarly, we identified a more aggressive disease progression in patients with lower ephrin-A5 protein levels in the cerebrospinal fluid without modifying disease onset....
16 In addition, LIPUS has been used in a mouse model of Alzheimer’s disease (AD), and its application resulted in elevated neurotrophic factor expression, increased neuron survival, and enhanced learning and memory functions.17,18 Moreover, LIPUS promotes neurological functions after stroke by ...
s ability to process and traffic a large portion of the proteome as well as regulate multiple processes in the cell such as mitosis, apoptosis, and migration, the dysregulation of ER–Golgi vesicular transport is associated with several pathologies such as Parkinson’s and Alzheimer’s disease,...
ECM remodeling [27]. IL-1β is another pro-inflammatory cytokine that initiates carcinogenesis and promotes immunosuppression. These functions of IL-1β are mainly observed in the early stages of carcinogenesis; moreover, its expression significantly impacts the process of malignant transformation [28]...