With this epidemiology, poor living conditions augment the endemicity of plague, which requires close contact with a rodent population. However, in endemic regions such as Madagascar, the lack of an approved vaccine means that outbreaks have to be controlled by antibiotic therapy, administered to t...
A medical procedure in which the therapy and/or treatment is tailored to a specific patient. Organoid biobanks Collections of organoid samples, typically of human origin, that are stored for research purposes and aim to encompass a wide range of population genetic variance. 3R principles A framew...
In addition to systemically delivered RNA nanoparticles, other modes of RNA application offer the potential to provide therapy to the nervous system75, eye76,77, heart78,79and lung80,81,82,83. Of particular note, nanoformulations based on both biodegradable polymers81and oligo polymers82as well ...
Pioneering gene therapy trials have shown that the genetic engineering of haematopoietic stem and progenitor cells can be an alternative to allogeneic transplantation in the treatment of primary immunodeficiencies. Early trials also highlighted the
there have been sev- eral studies on cancer therapy based on transformed stem cells, which have been shown to reduce tumor growth and increase patient sur- vival in various malignancies including melanomas, brain, liver, and breast tumors.112 Approaches for introducing genes into ...
differentaition to cortical neurons via 2D and 3D methods are discussed. Finally, applications for stem cell-derived neurons are depicted, namely drug screening, investigating disease mechanisms, in vivo transplantation of neuronal material to model organisms as well as the potential for cell therapy ...
5 SARS-CoV-2 application example: antiviral prophylaxis focus on peptide fusion inhibitors while 6 Molecular design principles of envelope-disrupting peptide inhibitors, 7 ZIKV application example: antiviral therapy focus on envelope-disrupting peptide inhibitors, followed by concluding remarks and outlook ...
E. Mechanism-based combination telomerase inhibition therapy. Cancer Cell 7, 1–2 (2005). Article CAS PubMed Google Scholar Herbert, B.-S. et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl Acad. Sci. USA 96,...
133. Suramin blocks the binding of viral RNA template strand within the RdRp catalytic site (Fig.6c) and inhibits SARS-CoV-2 replication in Vero E6 cells134. However, suramin has never been recommended for antiviral use because of its poor bioavailability and strong side effects (the negatively...
The barriers in vaccine therapy: Immune resistance Tumor-immune escape can be divided into intrinsic mechanisms determined by the characteristics of tumor cells and external mechanisms involving tumor matrix components (Fig.2). These two mechanisms determine the efficiency of cancer vaccines. ...