especially different types of T cells, that are grown and genetically engineered ex vivo before being re-administered to the patient as a therapy to identify and target cancer cells. In this regard, the most commonly used are Chimeric antigen receptor (CAR)-modified T cells (CAR T) therapy, ...
The Chinese president gave the example of China to explain the role an open economy plays in the development of a nation. He described China's achievements in boosting comprehensive reform and innovation, and enhancing inclusiveness and benefit-sharing in development. He also talked about the bluep...
Applications of brain organoid research. As part of a regenerative medicine therapy, pluripotent stem cells (PSCs) from brain organoids may be implanted to brain injury areas to heal damaged tissue or utilized to investigate brain illnesses. To simulate vascular and infectious disorders and investigat...
Infection through flea bite causes bubonic plague, which if undiagnosed, can develop into a septicemic infection or secondary pneumonic plague. Pneumonic plague is highly contagious requiring prompt antibiotic therapy for survival, as the mortality rate approaches 100% if untreated6,7,8. In pneumonic ...
With this epidemiology, poor living conditions augment the endemicity of plague, which requires close contact with a rodent population. However, in endemic regions such as Madagascar, the lack of an approved vaccine means that outbreaks have to be controlled by antibiotic therapy, administered to ...
In NSCLC, the development of tyrosine kinase inhibitors has made treatment for the tumor type a prime example of molecularly targeted therapy.2 However, similar progress has proved elusive in SCLC. Nearly all cases of SCLC are associated with smoking and its mutational profile reflects the impact ...
Colorectal cancer (CRC) is a common malignant tumor with the third and second highest incidence and mortality rates among various malignant tumors. Despite significant advancements in the present therapy for CRC, the majority of CRC cases feature profici
Tyrosine kinase inhibitors (TKIs) of EGFRs have been used as the standard first-line therapy for patients with advanced NSCLC, but the development of secondary resistance has led to treatment failure [44]. Paclitaxel is insoluble in water (less than 0.03 mg/ml), and due to this, the ...
overcome drug resistance. NPs containing HIF-1α siRNA can be used to reduce hypoxia-mediated drug resistance [144]. Instead of directly targeting HIF-1α, indirect inhibition of HIF-1α signaling can be used. For example, the “PI3K/Akt/mTOR pathway” is known to control the expression of...
Adoptive T cell therapy (ACT) has brought out unprecedented clinical outcomes in cancer immunotherapy as dysfunction of effector T cell is considered the central point for causing immune evasion by cancer cells. However, the main drawback of this method is the short-term immune response of adoptiv...