Cellular markers indicating a poor prognosis for ovarian cancer patients are disclosed. In particular, the invention relates to methods utilizing the frequency of a subset of cells in ovarian tumor tissue expressing vimentin, cMyc, or HE4, or any combination thereof, to predict an ovarian cancer ...
Fifty-three patients were treated in the gynaecological unit of the Mater Hospital for ovarian cancer between 1980-86. The demographic features of the patients reviewed were similar to those of the Southern Tumour Registry (1981-85), and in the absence of a national tumour registry are presumed...
the incidence of ovarian cancer is relatively low (5.0–9.4 per 100 000 women), and it shows the cumulative risk of 0.5–1.0% globally (Jemal et al, 2011). However, ovarian cancer is known to develop in 0.3–1.6% of women with endometriosis (Mostoufizadeh and Scully, 1980;Seidman, 1...
The identification of prognostic and predictive markers is crucial for choosing the most appropriate management method for ovarian cancer patients. We aimed to assess the prognostic role of tumor-associated macrophage (TAM) polarization in advanced ovarian cancer patients. We carried out a prospective ...
For more advanced cancers, functional status has consistently demonstrated an association with survival, although length of survival may depend on the underlying cancer. For example, for patients with metastatic cancer with relatively good treatment options, such as prostate or breast cancer, prognosis ...
Abarium enemamay be advised in patients to exclude colon cancer. Colonoscopyis preferred to barium enema to exclude metastasis to the colon. Biopsy Tissue samples for biopsy may be taken by means of laparoscopic surgery (through a tiny incision in the abdomen) when the tumor is small, or by...
While TOP2B were not found any significant prognostic value for EOC patients. From the Oncomine database, we also found widespread upregulation in the expression of TOP1 and TOP2A genes in primary tumor tissues. Albeit limited in number, all datasets exhibiting differential expression showed TOP...
Immunohistochemistry was used to analyze SEMA4D expression and tumor angiogenesis-related proteins (HIF-1α and VEGF) in tissues from 40 patients with normal ovarian epithelia and 124 EOC patients. SEMA4D was found to be expressed in 61.3 % of the 124 EOC tissues, which was significantly higher...
Plasma androgen levels also show a relationship with breast cancer risk that is weakened but not eliminated by 'correction' for estrogen levels. This has been argued to be evidence of the local production of estrogens being important in the etiology of breast cancer. Given that plasma steroid ...
This indicates that autophagy could be a factor in drug resistance and poor survival in clear cell ovarian cancer patients. This insight could lead to a better understanding of the role of autophagy under hypoxia in human ovarian cancer and could be a valuable biomarker for the development of ...