Do glial cells produce myelin?What Is Myelin:Myelin is a fatty coating that covers neurons to improve the efficiency of electrochemical signaling. Myelin covers the axon of neurons at specific intervals to allow for faster conduction of impulses, similar to how a plastic coating might insulate a ...
After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox...
To exclude this as a confounding factor, we compared myelin profiles in OL-Bace1cKO;AD and ExN-Bace1cKO;AD mice but found no changes (Extended Data Fig. 10c–g). The high expression level of amyloidogenic pathway genes in OLs was contrasted by the smaller relative contribution to overall A...
After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox...
In a previous study, the Göttingen researchers had already discovered that defective myelin of oligodendrocytes exacerbates Alzheimer's disease. Doglial cellsplay an even greater role in the disease than previously thought? "We have now shown that although neurons are the main producers of amyloid...
Step-by-Step Solution1. Identify the Cells that Produce Myelin Sheath: - The myelin sheath is produced by different types of cells depending on whether it is in the central nervous system (CNS) or the periph
A role for CXCL12 (SDF-1α) in the pathogenesis of multiple sclerosis: Regulation of CXCL12 expression in astrocytes by soluble myelin basic protein The pathogenic mechanisms that contribute to multiple sclerosis (MS) include leukocyte chemotaxis into the central nervous system (CNS) and the producti...
After central nervous system (CNS) demyelination鈥攕uch as occurs during multiple sclerosis鈥攖here is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre...
In the current study, we challenge the dogma that stimulation with the monokine IL-23 is universally required for the acquisition of pathogenic properties by myelin-reactive T cells. We show that IL-12-modulated Th1 cells readily produce IFN-γ and GM-CSF in the central nervous system (CNS)...
Qualitatively they express most jp locus features but suppress all shi locus features except abnormalities of myelin compaction. The difference between shi and shi mld has more influence on the double mutant morphology than the difference between jp and jp msd. In the 3-mutant combination, shi/...