解析 答案:Drug metabolism is the process by which the body breaks down and eliminates drugs. It typically involves two phases: Phase I reactions, which involve oxidation, reduction, or hydrolysis to make the drug more polar, and Phase反馈 收藏 ...
Describe the process of drug metabolism.搜索 题目 Describe the process of drug metabolism. 答案 解析 null 本题来源 题目:Describe the process of drug metabolism. 来源: 药学英语试题及答案 收藏 反馈 分享
The effect of fibrosis on drug metabolism in alcoholic liver disease was evaluated in a comparison of the concentrations of serum aminoterminal propeptide of type III procollagen and basement membrane (BM; 7S domain of type IV collagen and laminin) antigens with in vitro (cytochrome P-450) and...
During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through several steps, such as determination of drug availability (studies on pharmacokinetics), absorption, distribution, metabolism and elimination (ADME) and preliminary studies that ...
B. Plasma protein binding does not affect the bioavailability of a specific drug. C. A given drug in different dosage forms may show differences in bioavailability if given by the same route. D. Biopharmaceutical studies do not involve animal experiment. 查看答案解析 【判断题】 Much of our pre...
The Role of Metabolish Studies in Drug Safety Evaluation There is a general recognition now of the importance of drug metabolism studies in the process of drug development and the drug regulatory authorities certainly expect to see the results of such studies. However, it is not always appreci....
Phase 1:Phase 1 focuses on safety. About 20 to 80 healthy volunteers are recruited to establish a drug's safety and side effects and takes about 1 year. Absorption, metabolism and excretion of the drug are also emphasized. Phase 2:Phase 2 focuses on effectiveness. Roughly 40 to 300 patient...
four drugs are of oral usage and six compounds that lack vesicant or neurotoxicity could be delivered by IAC. We also identified promising compounds in preliminary phases of drug development including inhibitors of survivin, antiapoptotic Bcl-2 family proteins, methyltransferase, and kinesin proteins. ...
This approach represents a valuable computational filter in early drug discovery to identify compounds that may have p450 inhibition liabilities prior to ... Ekins,S. - 《Drug Metabolism & Disposition》 被引量: 151发表: 2003年 Structural insights into the promiscuity and function of the human preg...
Kivistö KT, Kroemer HK (1997) Use of probe drugs as predictors of drug metabolism in humans. J Clin Pharmacol 37:40–48 Article Google Scholar Fuhr U, Hsin C, Li X et al (2019) Assessment of pharmacokinetic drug–drug interactions in humans: in vivo probe substrates for drug metabolis...