AS Kalgutkar,D Dalvie - 《Drug Metabolism & Pharmacokinetics》 被引量: 26发表: 2014年 A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity The development of inhaled drugs for respiratory diseases is frequently impacted by lung pathology in non-clinical ...
Felix G, Berthod A (2007) Commercial chiral stationary phases for the separations of clinical racemic drugs. Part I: From alimentary tract and metabolism to cardiovascular system. Sep Purif Rev 36:285–481Felix G, Berthod A (2007) Commercial chiral stationary phases for the separations of ...
With respect to metabolism, the main focus of DDI strategies in pharmaceutical discovery and development programs are the cytochrome P450 (CYP) enzyme family, as CYP enzymes play a major role in drug clearance of marketed drugs. This chapter reviews common strategies for mitigation and managing ...
Diminished glucose uptake and metabolism in aged brains is a contributing factor to the bioenergetic basis of cognitive impairment. The efficacy of improved oxidative capacity in ameliorating cognitive function in both adult and aged (22-month-old) C57/6BJ mice was investigated using a 12-week ...
As the biological sciences have evolved, pharmacovigilance has slowly shifted toward earlier, proactive consideration of risks and potential benefits of drugs in the pre- and peri-approval stages of drug development, leading to a maturing of drug safety risk management. Further advances in biology, ...
For instance, cortisol modulates amygdala functional connectivity (FC) after stress (Chang and Yu, 2018; Clewett et al., 2013; Fan et al., 2015; van Marle et al., 2010; Veer et al., 2011) and affects activation and metabolism of mPFC, amygdala, and hippocampus (Jentsch et al., 2019...
(two-sided chi-square testp-value = 0.36) from that where the HHC developed disease 2–6 years after exposure to the IC (Fig.5). This suggests that mutations attributed to oxidative stress, or similar mutations that could be the result of alterations in bacterial metabolism are not ...
On the other hand, additional persistent pain states remain viable targets for this or similar drugs. Alternatively, it is possible that, in humans, CcL2 does not play as strong a role or perhaps is only one of many mediators ultimately converging on the same pathways to maintain pain in ...
[8], [9], [10], [11], but their application field has been expanded to a large variety of separations, including drug discovery and impurities in developmental drugs [7], [12], metabolism studies [13], [14], speciation analysis [15], water and fat soluble vitamins [16], and many ...
the olanzapine metabolism; in particular it decreases Fig. 1. Structural formulae of carbamazepine, olanzapine and the the half-life elimination and increases clearance and main metabolites. volume of distribution of olanzapine. This interaction seems to give no clinical effects since olanzapine has a...