Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediatorsFrancisellaSykPI3K/AktErkphagocytosisActive resolution of acute inflammation is a previously unrecognized interface between innate and adaptive immunity. Once thought to be a passive process, the resolution of inflammation is now...
The initiation and resolution of inflammation are important in host defense, each governed by bioactive lipid mediators (LMs) that drive the influx and function of immune cells, and eventually cell efflux and tissue repair.1,2 Newly identified families of bioactive LMs, biosynthesized from essential...
However, the current understanding is that it is a process tightly regulated by endogenous lipid mediators namely specialized pro-resolving lipid mediators (SPMs). SPMs are actively biosynthesized from the arachidonic acid (AA) and the omega-3 fatty acid molecules such as docosahexaenoic acid (DHA)...
The other targets are anti-inflammatory and pro-resolving lipid mediators, such as, resolvins and protectins, which are formed from EPA and DHA [3], [4]. In addition to the known ligands, chemerin and leukotriene B4 [5], [6], two G protein-coupled receptor (GPCR)s, namely, ChemR23...
An overview of these recent developments brings forth a novel repertoire of endogenous chemical signals and pathways that serve as antiinflammatory lipid mediators and also facilitate the resolution of acute inflammatory responses.SerhanCenterCharles
Tissueengineeringandregenerativemedicinehavecreatedademandforbiomaterialswithspeci,cfunctionssuchastheabilitytomodifythehostimmuneresponseTheobjectiveofthisstudywastoevaluatetheeffectoftwodifferentpro-resolutionlipidmediators,lipoxinA4(LxA4)andresolvinD1(RvD1),inthemodulationofthein,ammatoryresponsetobiomaterialsthrough...
Lipid mediators such as prostaglandins and leukotri- enes play pivotal roles in the initiation of acute inflammation [11], whereas resolvins and protectins promote and stimulate active resolu- tion [8,9,12]. In excess, prostaglandins and leukotrienes are generally pro-inflammatory [11] ...
Based on this hypothesis, it is suggested that progression and flares of IBD are not only due to increased production of pro-inflammatory molecules IL-6, TNF-α, MIF (macrophage migration inhibitory factor), HMGB1 (high mobility group box 1), free radicals and lipid mediators such as prostagla...
Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation Airborne exposure to microbial cell wall lipids such as lipopolysaccharide triggers innate immune responses that regulate susceptibility to allergic airway... ST Scanlon,SY Thomas,CM Ferreira,... - 《...
The connection(s) of these new lipid mediators to the control of an acute inflammation and its timely resolution are illustrated in this chapter. The chapter focuses on biosynthesis of proresolving mediators via cyclooxygenases and lipoxygenases. COX-2 also plays a key role in the biosynthesis ...