Ferroptosis is a cell death mechanism based on extensive cellular membrane peroxidation, implicated in neurodegenerative and other diseases. The essential oil component γ-terpinene, a natural monoterpene with a unique highly oxidizable pro-aromatic 1,4-cyclohexadiene skeleton, inhibits peroxidation of ...
tumor cell invasion and migration [18,19,20] but also is involved in regulating the process of ferroptosis, apoptosis, and necrosis [21,22,23]. However, it remains elusive whether ATF3 plays a role in regulation of glioma cell ferroptosis via promotion of intracellular H2O2accumulation. Brucine...
FerroptosisDivalent metal transporter 1SalinomycinIronLipid peroxidationDivalent metal transporter 1 (DMT1) inhibitors can selectively kill iron-addicted cancer stem cells by causing lysosomal iron overload, but their role in head and neck cancer (HNC) is unknown. We examined the role of DMT1 ...
Ferroptosis is a type of lipid peroxidation-induced, iron-dependent programmed cell death. Emerging evidence suggests that ferroptosis is intimately connected to tumorigenesis, development, treatment and plays a major role in tumor immune regulation. This study focused on the connecti...
Pro-oncogene FBI-1 inhibits the ferroptosis of prostate carcinoma PC-3 cells via the microRNA-324-3p/GPX4 axisdoi:10.7150/jca.96306ONCOGENESPROSTATE cancerAPOPTOSISMICRORNAGLUTATHIONE peroxidaseMingsheng LiuChenxiang XuHua YangQiyu JiangGuanyu Chen...
Results: PRODH expression is reduced in tamoxifen-resistant cells, and its overexpression enhances tamoxifen response in vitro and in vivo. Conversely, PRODH knockdown confers tamoxifen resistance in tamoxifen-sensitive cells. Mechanistic studies show that ferroptosis is inhibited in tamoxifen-resistant ...
NOD1 Macrophages Iron Ferroptosis CXCR2 Atherosclerosis 1. Introduction Iron is fundamental for the maintenance of life due to its contribution to essential metabolic and cellular processes (such as oxygen transport, energy production, detoxification or host defense); however, its dysregulation can lead ...
Pro-inflammatory cytokines are crucial mediators of beta-cell destruction in type 1 diabetes mellitus (T1DM). The involvement of ferroptosis as a form of oxidative non-apoptotic cell death in T1DM pathogenesis has not been elucidated so far. Moreover, the role of glutathione peroxidase 4 (GPx4)...
Ferroptosis is a novel form of iron-dependent cell death driven by lipid peroxidation, and recent studies have confirmed that ferroptosis plays an important role in the development of AML. However, the ferroptosis-related genes (FRGs) in PMF progression remain to be discovered. Methods: PMF‐...
BBOX1-AS1 up-regulated PROM2 expression, and re-expression of PROM2 reversed the effects of BBOX1-AS1 depletion on cell malignant phenotypes and ferroptosis. BBOX1-AS1 post-transcriptionally modulated PROM2 expression by sponging miR-326. MiR-326 was validated as a mediator of BBOX1-AS1 in...