In the case of sheep scrapie, the well- known role of variations in the prion protein gene (PRNP) in conferring resistance/susceptibility represents an opportunity which has been exploited to select populations genetically resistant to the disease. The recent description of Camel prion disease (...
gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1,...
Chuzheng Pan1, Xixi Liu1, Lin Zhou1,2, Beisha Tang1,2,3 & Lu Shen1,2,3 The prion protein (PRNP) gene is associated with prion diseases, whereas variants of the PRNP gene may also explain some cases of Alzheimer disease (AD) and frontotemporal dementia (FTD) in Caucasian...
Noun1.CJD- rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus; characterized by progressive dementia and gradual loss of muscle control Creutzfeldt-Jakob disease,Jakob-Creutzfeldt disease brain disease,brain disorder,encephalopathy- any disorder or disease ...
The structure of cellular prion proteins encoded by the prion protein gene (PRNP) impacts susceptibility to transmissible spongiform encephalopathies, including chronic wasting disease (CWD) in deer. The recent emergence of CWD in Northern European reind
朊蛋白(prion protein,prp)是被证明了的一种蛋白质浸染因子,在动物体内由单一基因组基因,即朊蛋白编码基因(polymorphisms of the prion protein gene,prnp)编码。prnp基因 c129和c219密码子多态性与神经退行性疾病的发生发展具有相关性。研究证实,prnp基因编码的prpc蛋白对aβ具有较高的亲和力,并且介导抑制长期增益...
This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, ...
This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, ...
(K) MBM ～. 本方所用缩略语 Alanine,丙氨酸 Ampicillin,氨苄青霉素 Amplification refractory mutation system,突变受阻性扩增系统 Arginine,精氨酸 Bovine spongiformencephalopathy,牛海绵状脑病 Creutzfeldt—Jakobdisease,克一雅氏症 centralnervous system,中枢神经系统 Chronic WastingDisease,慢性消耗性疾病 Cysteine,半胱...
We report here a case of Gerstmann-Str¤ussler-Scheinker (GSS) disease with a new mutation at the codon 232 (Met to Thr) of the PRNP gene. This case was characterized by PrP-immunopositive kuru and multicentric plaques; these plaques were also seen in the cerebral cortex, hippocampus and...