(2006): Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis. Neurobiol Aging 27, 770.e1-770.e5Bo, R., Scarlato, M., Ghezzi, S. (2006) Is M129V of PRNP gene associated with Alzheimer’s disease? A case-control study and a meta...
gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1,...
Noun1.CJD- rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus; characterized by progressive dementia and gradual loss of muscle control Creutzfeldt-Jakob disease,Jakob-Creutzfeldt disease brain disease,brain disorder,encephalopathy- any disorder or disease ...
This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, ...
gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1,...
(bovine spongiform encephalopathy) responsible for mad cow disease and the emergence of the human variant Creutzfeldt‒Jakob disease ([2,3], for reviews). Genetically, susceptibility or resistance to prions is mainly determined by polymorphisms of thePRNPgene, which encodes PrPc([4], for review...
chronic wasting disease PRNP : prion protein gene TSE: transmissible spongiform encephalopathy TSEs: transmissible spongiform encephalopathies CJD: Creutzfeldt-Jakob disease PrPC : protease-sensitive Cellular PRion Protein PrPSc : abnormal protease-resistant isoform of the prion protein BSE: bovin...
PrPC由朊蛋白基因(prion protein gene, PRNP)编码,小鼠的PRNP位于2号染色体,含有三个外显子,开放阅读框(ORF)全部位于第三个外显子[21]。PRNP在哺乳动物中具有高度保守性,所有动物的ORF都编码一个大小约为250个氨基酸的蛋白[21, 22]。PRNP多态性与物种对于朊蛋白疾病的易感性、临床表现和潜伏期等有着密切...
规格:10ug 50ug 100ug 200ug 1mg Recombinant Prion Protein (PRNP) Sequence Information Species:Human Gene ID:9128 Swiss Prot:O43172 Synonyms:CD230; GSS; ASCR; CJD; PRIP; PrP;PrP2730; PrPc; Major prion protein;Creutzfeldt-Jakob Disease;Gerstmann-Strausler-ScheinkerSyndrome; Fatal Familial Insomnia...
(TSE) of human being and some mammal.The polymorphisms of the prion protein gene (PRNP) are significantly affect the susceptibility or resistance to TSE for human being and mammal.In this paper, we analyzed the structure and function of the gene and coding protein.The relationship of mutations...