Discovering SNP-disease relationships in genome-wide SNP data using an improved harmony search based on SNP locus and genetic inheritance patternsdoi:10.1371/journal.pone.0292266HEREDITYMETAHEURISTIC algorithmsHUMAN genomeSEARCH algorithmsNUCLEOTIDE sequencing...
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This observation may be a reflection of stronger cis-eQTLs tending to have a smaller distance between SNP and gene42. In contrast, p-value estimates between two disease traits were comparable across the two window sizes. Partial correlations were computed where three-way relationships were observed...
at the genome-wide significant threshold (p < 5.0 × 10−8)23. The SNP effect sizes reported in the mbQTL GWAS summary statistics represent how the host genetic loci affect the relative abundance of each microbiome taxa (mbQTLs)23. In the present study, we limited our analyses ...
Chen YS, Olckers A, Schurr TG, Kogelnik AM, Huoponen K, Wallace DC (2000) mtDNA variation in the South African Kung and Khwe-and their genetic relationships to other African populations. Am J Hum Genet 66:1362–1383 PubMedCASGoogle Scholar ...
Disease risk SNPs were recognized using the risk score Rrisk, which depicted the relationship of a SNP with complex diseases and reflected the genetic effects of complex diseases. The risk score Rrisk of a SNP was calculated as we proposed in [41]:(1)Rrisk=logNcase(T)Ncontrol(T)ifNcase(...
“self” result in autoimmune disease. Bothgeneticregulation ofimmune celllevels and their relationships with autoimmunity are largely undetermined. Here, we report genetic contributions to quantitative levels of 95 cell types encompassing 272 immune traits, in a cohort of 1,629 individuals from four ...
We successfully identified 41 significant SNPs relevant to RA, 25 associated genes and a number of important SNP-SNP interactions (SNP patterns). Many findings (loci, genes and interactions) have experimental support from previous studies while novel findings may define unknown genetic pathways for ...
The effect (in years) on age at PD onset and 95% confidence intervals for the indicated genetic model are shown for each of the three independent samples and the combined analysis. A. Additive model of the A allele in SNP rs17565841 B. Dominant model of the A allele in SNP rs17565841 ...
The use of single nucleotide polymorphism (SNP) arrays including more than one million markers randomly chosen to cover the genome recently allowed genome-wide association (GWA) studies to be performed in complex and monogenic diseases; however, to obtain the statistical evidence needed to prove an...