An inhibitor of PRMT5 would in all likelihood augment the effects of drugs (such as the nutlins) that restore p53. Inhibition of PRMT5, resulting in decreased arginine-methylated p53, may sensitize tumour cells to chemo- and radiotherapy by switching, or at least biasing, the cellular outcome...
Conclusions This is the first study evaluating a PRMT5 inhibitor. Overall, AEs were common but manageable. Patients with multiple tumor types responded to therapy. Part 2 of the study is open for subjects with predefined solid tumors and non-Hodgkin's lymphoma. Clinical trial identification NCT...
用于治疗或预防PRMT5介导的疾病的化合物.pdf,本公开涉及适合于抑制蛋白质精氨酸甲基转移酶(PRMT),特别是PRMT5的化合物。这些化合物可以用作治疗剂,特别是用于治疗和/或预防增殖性疾病例如癌症的治疗剂。(19)中华人民共和国国家知识产权局 (12)发明专利申请 (10)申请公布号
国籍:美国 网址:https://www.targetmol.com/ 产品总数:32159 公司提供产品列表 PRMT5-IN-1PRMT5-IN-12366149-83-7 Rilzabrutinib瑞扎布鲁替尼1575596-29-0 Proanthocyanidin A4原花青素A4111466-29-6 Proglumide hemicalcium85068-56-0 Prolyl Endopeptidase Inhibitor 1;BPP;Boc-Pro-prolinal;(Boc)-Prolyl-proli...