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Primary ovarian insufficiency (POI) is defined as the development of primary (hypergonadotropic) hypogonadism before the age of 40 years. The diagnostic criteria of POI are irregular menses in women before the age of 40 years in association with follicle-stimulating hormone level in the ...
Primary ovarian insufficiency or premature menopause is one of the stressful problems in women younger than 40, which may cause numerous early or late psychological and physical complications. Failure of germ cell development is associated with complete ovarian insufficiency, while their decreased number ...
Primary ovarian insufficiency (POI) is a syndrome of amenorrhoea, sex steroid deficiency, and elevated gonadotropins in a woman aged more than two standard deviations below the mean age for menopause estimated for her reference population. In practical terms, it occurs spontaneously in 1 % of ...
Context: The etiology of primary ovarian insufficiency (POI) remains unknown in a majority of cases. Objective: We sought to identify genes causing POI. Design: The study was a familial genetic study. Setting: The study was performed in two academic institutions. Patients: We identified a consan...
POI, primary ovarian insufficiency; hPMSC, human placenta-derived mesenchymal stem cell; DMSO, dimethylsulfoxide; and PI3K, phosphatidylinositol 3-kinase [67]. Other studies involving the pathways JNK/Bcl2, IRE1α, NGF/TrkA, and SMAD have been reported. Yin et al. [69] suggested that the ...
Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction characterized by premature exhaustion of primordial follicles. POI causes infertility, severe daily life disturbances and long-term health risks. However, the underlying me
(redirected fromPrimary ovarian failure) Thesaurus Medical Encyclopedia men·o·pause (mĕn′ə-pôz′) n. 1.The permanent cessation of menstruation, usually occurring between the ages of 45 and 55. 2.The period during which such cessation occurs. In both sense, also calledclimacteric. ...
Primary ovarian insufficiency is the depletion or dysfunction of ovarian follicles with cessation of menses before age 40 years. There is no consensus on criteria to identify primary ovarian insufficiency in adoles-cents, and delay in diagnosis is common. Health care providers who make this clinical...
Women with primary ovarian insufficiency (POI) may be more burdened by cardiovascular disease, such as myocardial infarction and stroke, as compared with women with normal menopause. The increased burden may be mediated by a worsening of cardiovascular risk factors, such as lipids, corresponding with...