The article offers information on primary ovarian insufficiency, which is a subclass of ovarian dysfunction. Possible causes are genetic defects, chemotherapy, radiotherapy or surgery. Main symptom is absence of regular menstrual cycles, and diagnosis is by detection of follicle-stimulating hormone and ...
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primary ovarian insufficiencyovarian failuregenome wide association studies (GWAS)whole-exome sequencing (WES)next generation sequencing (NGS)genetic counselingfertility guidanceA Clinical Guide to Early Menopausedoi:10.1007/978-3-319-22491-6_2Santoro, Nanette F....
Primary Ovarian Insufficiencyprimary ovarian insufficiencyovarian failuregenome wide association studies (GWASwhole-exome sequencing (WESnext generation sequencing (NGSgenetic counselingfertility guidancePrimary ovarian insufficiency or premature menopause is one of the stressful problems in women younger than 40,...
Context: The etiology of primary ovarian insufficiency (POI) remains unknown in a majority of cases. Objective: We sought to identify genes causing POI. Design: The study was a familial genetic study. Setting: The study was performed in two academic institutions. Patients: We identified a consan...
Once primary ovarian insufficiency is diagnosed, patients should be evaluated at least annually. The goals of hormonal therapy extend beyond simply symptom relief to levels that support bone, cardiovascular, and sexual health. Referrals to a reproductive endocrinology and infertility specialist should be ...
Primary ovarian insufficiency (POI) is the cessation of ovarian function before the age of 40. The causes of POI are heterogeneous, but substantial evidence exists to support a genetic basis of POI, particularly in the critical involvement of genes on the X chromosome. Recent studies have reveale...
Primary ovarian insufficiency (POI) is a subclass of ovarian dysfunction in which the resting pool of primordial follicles is prematurely exhausted. It occurs through two major mechanisms: a pathologic process that causes follicle dysfunction or development of an inadequate initial pool of primordial ...
insufficiency/premature ovarian aging that affects at least 1% of the female population10,11,12,13,14. Cellular senescence is linked to age-related phenotypes and diseases15. In tissues with active cell turnover, senescence is a cellular fate that cells undergo a stable, permanent cell-cycle arr...
Primary ovarian insufficiency (POI) is a syndrome of amenorrhoea, sex steroid deficiency, and elevated gonadotropins in a woman aged more than two standard deviations below the mean age for menopause estimated for her reference population. In practical terms, it occurs spontaneously in 1 % of ...