Medical treatment has always been the mainstay in the management of primary open-angle glaucoma (POAG). Surgical intervention has been reserved for cases with intraocular pressures uncontrolled on medical therapy and/or progression of visual field loss. Following the introduction of trabeculectomy, ...
We performed a genome-wide association study for primary open-angle glaucoma (POAG) in 1,007 cases with high-pressure glaucoma (HPG) and 1,009 controls from southern China. We observed genome-wide significant association at multiple SNPs nearABCA1at 9q31.1 (rs2487032;P= 1.66 × 10−8) ...
来自 NCBI 喜欢 0 阅读量: 76 作者:J Alvarado,C Murphy,R Juster 摘要: The trabecular meshwork cellularity (cells/unit tissue area) was compared in patients with primary open-angle glaucoma (POAG) with that of nonglaucomatous (NG) individuals. The NG specimens (n = 69) include specimens from...
There is extensive evidence that there is a genetic component to developing primary open-angle glaucoma (POAG). Unraveling this genetic component might clarify the pathophysiology of the disease and greatly assist in treatment and prevention of visual loss of many thousands of individuals. Linkage and...
4 Shields MB: Staging glaucoma for the twenty-first century: sixth Chandler-Grant Lecture. J Glaucoma 1996; 5: 340–344. 5 Wiggs JL, Damji KF, Haines JL, Pericak-Vance MA, Allingham RR: The distinction between juvenile and adult-onset primary open-angle glaucoma. Am J Hum Genet 1996; ...
Mutation analyses of two large cohorts of patients with POAG, normal tension glaucoma (NTG) and juvenile open-angle glaucoma (JOAG), and control subjects, found only association of non-synonymous heterozygous variants of the retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) with...
来自 NCBI 喜欢 0 阅读量: 59 作者: XH Sun 摘要: 43 cases (86 eyes) of primary chronic angle-closure glaucoma (PCACG) and 44 cases (77 eyes) of primary acute angle-closure glaucoma (PAACG) randomly selected, and 30 normal subjects (34 eyes) were performed ultrasonic biometry of anterior...
Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness worldwide. Increasing evidence suggests oxidative damage and immune response defects are key factors contributing to glaucoma onset. Indeed, both the failure of the trabecular meshwork tissue in the conventional out...
There is no direct evidence that microbial infection can cause acute angle closure; however, case reports and case series have described acute angle closure in systemic infection (Table 4). In 1976, Saari first reported acute glaucoma in 3 patients with hemorrhagic fever with renal syndrome caused...
Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness on a global level. Researchers have yet to specify the exact mechanisms of POAG; the respective relationships between POAG and elevated intraocular pressure (IOP), as well as optic neuropathy, remain particularly unclear...