The mechanism(s) by which hyperthermia affects neuronal activity is currently unknown. However, hyperthermia affects many cellular processes that could influence neuronal activity. For instance, hyperthermia impairs energy metabolism and in turn reduces antioxidant defences (Skibba et al., 1991; Flanagan ...
thereby increasing the concentration of dopamine in the synaptic cleft [2]. Amphetamines also interact with the vesicular monoamine transporter 2 (VMAT2), leading to increasing amounts of dopamine in the cytosol, a possible mechanism of action for the neurotoxicity of amphetamines. Neurotoxic effects ...