BRAIN damageN-Methyl-3, 4-methylenedioxyamphetamine (MDMA), or ecstasy is a recreational drug of abuse. It is a synthetic substance that affects the body's systems, which its mechanism of action and treatment should be more investigated. MDMA provides an immediate enjoyable...
Recent studies have demonstrated a similar acute effect of (MDMA) in blood platelets and brain tissue via action on the transporter. To investigate the validity of blood as a peripheral marker for central in this regard, we administered MDMA (20 mg/kg i.p.) to and observed a parallel decre...
New Insights into the Mechanism of Action of Amphetamines into the molecular mechanisms whereby amphetamine, and the closely related compounds methamphetamine and methylenedioxymethamphetamine, cause monoamine, and particular... AE Fleckenstein,TJ Volz,EL Riddle,... - 《Annu Rev Pharmacol Toxicol》 被引...
MDMA is generally agreed to be a potent indirect monoaminergic agonist, raising synaptic levels of monoamines by at least three different mechanisms: increased release, inhibited uptake (both related to action on the transporters), and MAO inhibition (Morgan, 1998; Green et al., 2003; Escobedo...
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These differences may be attributable to their differing mechanisms of action. MDMA-related effects in the brain are widespread; it potently releases the mono- amine neurotransmitters dopamine, serotonin, and norepi- nephrine in part by inducing carrier-mediated release through their respective ...
30.Marona‑Lewicka D,Nichols DE(2007).Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action.Pharmacology,biochemistry, and behavior 87:453‑461. 31.Marona‑Lewicka D,Thisted RA,Nichols DE(2005)....
The blissful and euphoric effects of the substance are brought on by the enhanced release and inhibited reuptake of the neurotransmitters serotonin, dopamine, and norepinephrine. This action increases the number of neurotransmitters within the synaptic cleft of neurons, causing the user to feel the eff...
The Molecular Mechanism of MDMA ("ecstasy") has been widely reported as a drug of abuse and as a neurotoxin. This report describes the mechanism of MDMA action at serotonin transporters from plasma membranes and secretory vesicles. MDMA stimulates serotonin efflux... G Rudnick,SC Wall 被引量:...
The drug MDMA, commonly known as ecstasy, produces a specific and distinct open hearted mental state, which led to the creation of a new pharmacological class, “entactogens”. Extensive literature on its mechanisms of action has come to characterize MDMA as a “messy” drug with multiple mech...