has not been definitively demonstrated that deficits are related to MDMA-induced 5-HT injury. Future research should be directed toward determining the mechanism of action of MDMA neurotoxicity, defining the pa
The major focus of this chapter addresses MDMA's effects on the human nervous system. To this end, MDMA's mechanism of action and its effects on the sympathetic nervous system are first detailed. The ensuing discussion addresses MDMA's effects on the central nervous system, including its ...
30.Marona‑Lewicka D,Nichols DE(2007).Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action.Pharmacology,biochemistry, and behavior 87:453‑461. 31.Marona‑Lewicka D,Thisted RA,Nichols DE(2005)....
MDMA has direct action on the serotonin, dopamine, and norepinephrine neurochem- ical systems (Climko et al, 1986), suggesting that an interaction of the two drugs may occur within the dopamine system. Both THC and MDMA are also known to strongly affect cholinergic release in areas critically ...
MDMA (3, 4-methylenedioxymethamphetamine) belongs to a unique class of psychoactive compounds–‘entactogens’–that share similarities in chemical structure with both classical stimulants and psychedelics (Nichols, 1986;Gouzoulis-Mayfrank, 2001). The potent action of MDMA at the serotonin transporter...
The blissful and euphoric effects of the substance are brought on by the enhanced release and inhibited reuptake of the neurotransmitters serotonin, dopamine, and norepinephrine. This action increases the number of neurotransmitters within the synaptic cleft of neurons, causing the user to feel the eff...
But there’s clearly something there– empirically, we see that some people are more ‘tuned in’ to the emotional & interpersonal realm, more skilled at feeling the energy of the room, more adept at making others feel comfortable, better at inspiring people to belief and action. It would ...
[45] It also acts as a weak 5-HT1 and 5-HT2 receptor agonist, and its more efficacious metabolite MDA likely augments this action.[46][47][48][49] MDMA's unusual entactogenic effects have been hypothesized to be, at least partly, the result of indirect oxytocin secretion via ...
Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy exam- ined with PET and [carbonyl-(11)C]WAY-100635. Nucl Med Biol 27: 509–513. Ramaekers JG, Kuypers KP, Wingen M, Heinecke A, Formisano E (2009). Involvement of inferior parietal ...
MDMA has direct action on the serotonin, dopamine, and norepinephrine neurochemical systems (Climko et al, 1986), suggesting that an interaction of the two drugs may occur within the dopamine system. Both THC and MDMA are also known to strongly affect cholinergic release in areas critically ...