Irregularities in the development, maintenance, and function of this cellular component lead to a range of clinical manifestations known as ciliopathies. The majority of people with ciliopathies have a high prevalence of retinal degeneration. The most common theory is that retinal degeneration is ...
The structure, length and function of the primary cilium must be tightly controlled because their dysfunction is associated with disease. Caveolin 1 (Cav1), which is best known as a component of membrane invaginations called caveolae, is also present in non-caveolar membrane domains whose function...
However, in PBC but not controls, a 50-kilodalton antigen was detected in the plasma membrane-enriched fraction. This antigen comigrated with component X of purified human heart PDC and was recognized by antibodies specific for PDC-X. CONCLUSIONS: The data suggest that PDC-X or a cross-...
which surveyed data for the overall US population (excluding pregnant women, institutionalized individuals and military personnel) in all age and racial groups between 1999 and 2004 found that men regardless of race and ethnicity had a higher ...
To ensure the quality of our omics results, we performed principal component analysis (PCA) to verify if our manipulations resulted in variation between sample groups in all omics experiments performed (Additional file 1: Fig. S2 A–D). When using as PCA loadings either transcript counts, lipid...
Comparing the metabolomes of organisms that are critical to ecosystem functioning (i.e., ecosystem engineers) is poised to become a crucial component of Ecosystem- and Resilience-Based Management23,24. Comparative metabolomics will help define and characterize the chemical crosstalk that controls the ...
Thorley-Lawson, D.A.; Poodry, C.A. Identification and isolation of the main component (gp350-gp220) of Epstein-Barr virus responsible for generating neutralizing antibodies in vivo.J. Virol.1982,43, 730–736. [Google Scholar] [CrossRef] [PubMed] ...
Although sphingomyelin was initially considered only a structural component of plasma membrane, several investigations established the involvement of sphingolipids and its metabolites in the key events of signal transduction associated with cell regulation, cell differentiation, and apoptosis (10, 11). Be...
Interestingly, as phosphatidylcholine serves as a crucial component of bile, a separate study reported a decrease in phosphatidylcholine levels in the bile of PSC patients [46]. The biliary epithelium, akin to other mucosal surfaces, is regarded as a protective surface that secretes mucus to ...
Interestingly, as phosphatidylcholine serves as a crucial component of bile, a separate study reported a decrease in phosphatidylcholine levels in the bile of PSC patients [46]. The biliary epithelium, akin to other mucosal surfaces, is regarded as a protective surface that secretes mucus to ...