Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection. Blood. 2005;106(9):2995-3003.Moeller, M.; Haynes, N.M.; Kershaw, M.H.; Jackson, J.T.; Teng, M.W.; Street, S.E.; Cerutti, L.; Jane, S.M.; Trapani, J.A.; Smyth...
Helper T cells (also called CD4 cells) signal B cells to start making antibodies. They also can activate macrophages. Macro-phages are immune system cells that engulf foreign cells and process them so they can be destroyed by other cells, such as killer T cells and natural killer cells (...
摘要: The latency of human immunodeficiency virus-type 1 (HIV-1) in resting primary CD4+ T-cells is the major barrier for viral eradication in patients on suppressive highly active antiretroviral therapy (HAART).Even with optimal HAART treatment...
Primary Sjögren’s syndrome (pSS) is a prevalent autoimmune disorder wherein CD4+T cells play a pivotal role in its pathogenesis. However, the underlying mechanisms driving the hyperactivity of CD4+T cells in pSS remain poorly understood. This study aimed to investigate the potential role of i...
CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis Lv S, Chen L, Li B, Gershwin ME, Wang FS (2015) CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis... L Wang,S Ying,Z Zhang,... - 《Hepato...
Th17 cells in primary Sjögren’s syndrome: pathogenicity and plasticity. J Autoimmun. 2018;87:16–25. Article CAS PubMed Google Scholar Hsu H-C, Yang P, Wang J, Wu Q, Myers R, Chen J, et al. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive ...
Here, we present the method called “primary T cell crisprQTL,” a high-throughput, single-cell, pooled CRISPRi-based functional screening framework to map non-coding regulatory elements to genes in primary human CD4+ T cells. We perturbed transcription start sites (TSSs) and putative regulatory...
Here, we present the method called “primary T cell crisprQTL,” a high-throughput, single-cell, pooled CRISPRi-based functional screening framework to map non-coding regulatory elements to genes in primary human CD4+ T cells. We perturbed transcription start sites (TSSs) and putative regulatory...
Platelet autoantigens are abnormally recognized, processed, and presented by DCs, and then CD4+ T helper cells are activated toward a proinflammatory profile, which dictate the differentiation of B cells into autoantibody-secreting plasma cells. Autoantibodies not only mediate platelet phagocytosis by ...
CD4 help deficiency diminished the generation of VACV-specific CD81 T cells after intraperitoneal (i.p.) but not after intranasal (i.n.) infection. A large viral dose could not restore normal expansion of VACV-specific CD81 T cells in i.p. infected MHC II2/2 mice. In contrast, ...