Lastly, we integrate genetic association data for immune-related traits and demonstrate how our platform can aid in the identification of effector genes for GWAS loci. Conclusions We describe “primary T cell crisprQTL” — a scalable, single-cell functional genomics approach for mapping regulatory ...
In clinical practice, to aid breast reconstruction, autologous fat tissues are often grafted to the surgical site during lumpectomy [[15], [16], [17]]. We envision approaches that can take advantage of the fat tissue graft to deliver drugs and manage the residual cells hold promise to reduc...
authors hope that the study may be helpful for policy-makers with the progressive changes in education and government support for informatics, especially in Poland, in making informed decisions to aid the transition into distance education as well as developing preparedness plans for future pandemics....
The municipal water treatment is also known as the sewage or wastewater treatment. It is the process of removing all kinds of containments from the sewage. It allows production of clean waste that can be reuse or dispose in environmental friendly way. ...
Advancements in genetic knowledge aid in creating management strategies for pNET patients, but the main molecules responsible for liver metastasis remain unknown. Although therapies targeting somatostatin receptors (SSTR) are safe and effective for difficult pNET cases, they primarily focus on SSTR2. ...
The microenvironment of lymph node metastasized tumors (LNMT) determines tumor progression and response to therapy, but a systematic study of LNMT is lacking. Here, we generate single-cell maps of primary tumors (PTs) and paired LNMTs in 8 breast cancer
Chimeric antigen receptor (CAR)-modified natural killer (NK) cells show antileukemic activity against acute myeloid leukemia (AML) in vivo. However, NK cell-mediated tumor killing is often impaired by the interaction between human leukocyte antigen (HLA)
et al. 70-gene signature as an aid to treatment decisions in early-stage breast cancer. N. Engl. J. Med. 375, 717–729 (2016). 25. Bassez, A. et al. A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer. Nat. Med. 27, 820–832 (...
International Journal of Molecular Sciences Article Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration Ruxandra Anton 1, Mihail Ghenghea 1, Violeta Ristoiu 1, Christophe Gattlen 2 , Marc-Rene Suter 2 , Petre Alexandru Cojocaru 3,4 ...
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