We expect that the combination of cancer genomics with high-resolution characterization of the tumor microenvironment will aid in further understanding of the interplay between tumor evolution and the immune sy
We thank Chen Li from the Welch lab for his invaluable advice and aid with single-cell data analysis. We thank the University of Michigan Flow Cytometry Core and Advanced Genomics Core for assistance with experiments, particularly Wenpu Trim and Tricia Tamsen. Thank you to all members of the ...
Lastly, we integrate genetic association data for immune-related traits and demonstrate how our platform can aid in the identification of effector genes for GWAS loci. Conclusions We describe “primary T cell crisprQTL” — a scalable, single-cell functional genomics approach for mapping regulatory ...
www.nature.com/scientificreports OPEN Primary and secondary aerenchyma oxygen transportation pathways of Syzygium kunstleri (King) Bahadur & R. C. Gaur adventitious roots in hypoxic conditions Hong‑Duck Sou1,2*, Masaya Masumori2, Takashi Yamanoshita2 & Takeshi Tange2 Some ...
Knowledge of biogenesis features will aid in interpreting human mutations. For example, reduced miR-16 expression associated with chronic lymphocytic leukemia (CLL) is typically due to deletions spanning the intron containing mir-15a and mir-16-1 (Calin et al., 2002). However, 2 of 75 CLL pat...
(Fig.6e). The analysis also provided further evidence that c9 is an OC cluster based onTNFRSF11A(RANK) enrichment when contrasted with macrophage, but not when contrasted to mature OCs42. Lastly, we used pySCENIC’s regulon specificity scoring to better define the transcription factors active ...
Fig. 1: Acute depletion of BRG1 with auxin-inducible degron (AID) system in mouse T cells results in significant decreases in BRG1 binding genome-wide. aWestern blotting shows efficient depletion of BRG1 by Auxin treatment for 6, 10, and 24 h. Primary CD4 + T cells were isolated ...
www.nature.com/scientificreports OPEN Primiparous sow behaviour on the day of farrowing as one of the primary contributors to the growth of piglets in early lactation Océane Girardie 1*, Denis Laloë 2, Mathieu Bonneau 3,Yvon Billon 4, Jean ...
There was also a shift in cel- lular proportions in the TME of NST ER−/HER2− tumors between obese and lean patients, with fibroblasts increasing and macrophages/ monocytes decreasing, while T cells remained the most prevalent cell type (Fig. 6e, Supplementary Data 19). In terms of ...
Chimeric antigen receptor (CAR)-modified natural killer (NK) cells show antileukemic activity against acute myeloid leukemia (AML) in vivo. However, NK cell-mediated tumor killing is often impaired by the interaction between human leukocyte antigen (HLA)