The term "primary age‐related tauopathy" (PART) was recently introduced to describe a pathology that is commonly observed in the brain of aged individuals. Symptoms in persons with PART usually range from normal cognition to amnesia. The aim of the study is to explore the tau aggregates ...
Chronic traumatic encephalopathy and primary age‐related tauopathyCHRONIC traumatic encephalopathyALZHEIMER'S diseasedoi:10.1002/ana.25860Yi〩e ChenQing㏎ing TaoAnnals of Neurology
Primary age-related tauopathy (PART) is a form of Alzheimer-type neurofibrillary degeneration occurring in the absence of amyloid-beta (Aβ) plaques. While PART shares some features with Alzheimer disease (AD), such as progressive accumulation of neurofibrillary tangle pathology in the medial tempora...
Shared and Distinct Epigenetic Profiles in Primary Age‐Related Tauopathy and Alzheimer's Disease: Insights into Tangle Formation and Spread doi:10.1002/alz.092601Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationWadhwani, Anil RGoldberg, DavidWolk, David ALee, Eddie B...
doi:10.1016/j.jalz.2018.06.3043Lilah M. BesserCharles MockMerilee TeylanJason HassenstabWalter A. KukullJohn CraryAlzheimer's & Dementia
By contrast, tau pathology in Pick's disease (PiD) (3R), Alzheimer's disease (AD) (3R/4R), and primary age-related tauopathy (PART) (3R/4R) is largely limited © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 ...
(TDP-43) with Frontotemporal Dementia and Limbic predominant Age-related TDP-43 Encephalopathy (LATE) [90]. In addition, positron emission tomography (PET) tracers that bind to these pathological aggregates are gaining traction in clinical practice after being employed in research for many years [...
Albeit being classified as a secondary tauopathy due to the association of tau pathology with amyloidosis, Alzheimer's disease (AD) is the most prevalent tauopathy amongst at least twenty others1,2. It has been established that tau pathology correlates more strongly with AD cog- nitive ...
(Egger, van Giesen, Moraru, & Sprecher, 2013; Reinecke et al., 2011). Primary culture is particularly useful for studying tauopathy sinceneuronal culturescan be created from flies with any genetic background, including flies expressing genes under control of the UAS-GAL4 system. This protocol...
by phosphorylation of tau at several identified phosphorylation sites in the protein reducing its affinity for microtubules2,9,10. In experimental models of tauopathy, tau has been shown to seed pathology causing it to aggregate in the cytoplasm and to spread to postsynaptic neurons in a prion-li...